No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa

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dc.contributor.authorVergotine, Zelda
dc.contributor.authorKengne, André Pascal
dc.contributor.authorErasmus, Rajiv Timothy
dc.contributor.authorMatsha, Tandi Edith
dc.date.accessioned2021-10-08T07:20:28Z
dc.date.available2021-10-08T07:20:28Z
dc.date.issued2014
dc.description.abstractBACKGROUND: The most common single-nucleotide polymorphism in the insulin receptor substrate-1 (IRS1) gene is Gly972Arg, which is associated with a 25% increased risk of developing diabetes. The mixed-ancestry population of South Africa (SA) has one of the highest prevalences of type 2 diabetes mellitus (T2DM) in Africa. OBJECTIVE: To report the frequency of IRS1 Gly972Arg and investigate its associations with cardiometabolic traits. METHODS: DNA from 856 mixed-ancestry adults drawn from an urban community of Bellville South, Cape Town, SA, was genotyped by two independent laboratories. Oral glucose tolerance tests were performed and cardiometabolic risk factors measured. RESULTS: A total of 237 (24.7%) participants had T2DM. The IRS1 Gly972Arg variant was present in 7.9% of the individuals studied and only one participant (non-diabetic) carried the homozygous A/A variant. In linear and logistic regression analyses, Gly972Arg was not associated with obesity, insulin resistance/sensitivity or T2DM. CONCLUSIONS: The prevalence of the Gly972Arg variant in the mixed-ancestry population of SA is comparable to that reported in African Americans, but its presence is not associated with cardiometabolic traits. This suggests that the Gly972Arg variant may not aid diabetes risk evaluation in this setting, nor can such information help explain the high prevalence of diabetes previously reported in this population.
dc.identifier.apacitationVergotine, Z., Kengne, A. P., Erasmus, R. T., & Matsha, T. E. (2014). No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa. <i>South African Medical Journal</i>, 104(6), 420 - 177. http://hdl.handle.net/11427/34927en_ZA
dc.identifier.chicagocitationVergotine, Zelda, André Pascal Kengne, Rajiv Timothy Erasmus, and Tandi Edith Matsha "No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa." <i>South African Medical Journal</i> 104, 6. (2014): 420 - 177. http://hdl.handle.net/11427/34927en_ZA
dc.identifier.citationVergotine, Z., Kengne, A.P., Erasmus, R.T. & Matsha, T.E. 2014. No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa. <i>South African Medical Journal.</i> 104(6):420 - 177. http://hdl.handle.net/11427/34927en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Vergotine, Zelda AU - Kengne, André Pascal AU - Erasmus, Rajiv Timothy AU - Matsha, Tandi Edith AB - BACKGROUND: The most common single-nucleotide polymorphism in the insulin receptor substrate-1 (IRS1) gene is Gly972Arg, which is associated with a 25% increased risk of developing diabetes. The mixed-ancestry population of South Africa (SA) has one of the highest prevalences of type 2 diabetes mellitus (T2DM) in Africa. OBJECTIVE: To report the frequency of IRS1 Gly972Arg and investigate its associations with cardiometabolic traits. METHODS: DNA from 856 mixed-ancestry adults drawn from an urban community of Bellville South, Cape Town, SA, was genotyped by two independent laboratories. Oral glucose tolerance tests were performed and cardiometabolic risk factors measured. RESULTS: A total of 237 (24.7%) participants had T2DM. The IRS1 Gly972Arg variant was present in 7.9% of the individuals studied and only one participant (non-diabetic) carried the homozygous A/A variant. In linear and logistic regression analyses, Gly972Arg was not associated with obesity, insulin resistance/sensitivity or T2DM. CONCLUSIONS: The prevalence of the Gly972Arg variant in the mixed-ancestry population of SA is comparable to that reported in African Americans, but its presence is not associated with cardiometabolic traits. This suggests that the Gly972Arg variant may not aid diabetes risk evaluation in this setting, nor can such information help explain the high prevalence of diabetes previously reported in this population. DA - 2014 DB - OpenUCT DP - University of Cape Town IS - 6 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2014 SM - 0038-2469 T1 - No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa TI - No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa UR - http://hdl.handle.net/11427/34927 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34927
dc.identifier.vancouvercitationVergotine Z, Kengne AP, Erasmus RT, Matsha TE. No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa. South African Medical Journal. 2014;104(6):420 - 177. http://hdl.handle.net/11427/34927.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue6
dc.source.journalvolume104
dc.source.pagination420 - 177
dc.source.urihttps://dx.doi.org/10.7196/SAMJ.7419
dc.subject.otherObesity
dc.subject.otherDiabetes Mellitus, Type 2
dc.subject.otherInsulin Resistance
dc.subject.otherInsulin Receptor Substrate Proteins
dc.subject.otherDNA
dc.subject.otherPolymorphism, Single Nucleotide
dc.subject.otherGenes
dc.subject.otherLogistic Models
dc.subject.otherRisk Factors
dc.subject.otherRisk
dc.subject.otherPrevalence
dc.subject.otherGlucose Tolerance Test
dc.subject.otherHomo sapiens
dc.subject.otherInsulin receptor substrate-1
dc.subject.otherGly972Arg
dc.subject.otherDiabetes
dc.subject.otherInsulin resistance
dc.titleNo evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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