Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria
| dc.contributor.author | Ocheke, I. E | |
| dc.contributor.author | Mohamed, S. | |
| dc.contributor.author | Okpe, E. S | |
| dc.contributor.author | Bode-Thomas, F. | |
| dc.contributor.author | McCullouch, M. I | |
| dc.date.accessioned | 2019-12-10T08:49:58Z | |
| dc.date.available | 2019-12-10T08:49:58Z | |
| dc.date.issued | 2019-11-12 | |
| dc.date.updated | 2019-11-17T04:13:56Z | |
| dc.description.abstract | Abstract Introduction Evidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of kidney damage associated with SCA is microalbuminuria. Our objective was to determine the risk factors of microalbuminuria in these children and its relationship with estimated glomerular filtration rate. Methods This was a cross-sectional and comparative study involving three hundred and twenty three children with SCA in steady state and equal numbers of apparently healthy age and sex matched haemoglobin AA (HbAA) control, aged 6 months to 18 years. They were consecutively recruited over a 6 month period. Result Microalbuminuria was present in 26% of the study subjects compared with 1.85% of control P = 0.001). Anaemia and high estimated glomerular filtration rate (eGFR) showed strong positive correlation with microalbuminuria (OR = 3.19, CI 0.953–1.116, p = 0.003 and OR = 1.7, CI 1.042–1.066, p = 0.001 respectively). Similarly, eGFR was higher in subjects with SCA than in controls and as well as in those with microalbuminuria compared with those who do not (p = < 0.01). Conclusions The two most important risk factors for microalbuminuria were anaemia and high eGFR. Age category was associated more with microalbuminuria than just age as a variable. Glomerular filtration rate was higher in children with microalbuminuria than those who do not and it was also higher in children with SCA than in control. | |
| dc.identifier.apacitation | Ocheke, I. E., Mohamed, S., Okpe, E. S., Bode-Thomas, F., & McCullouch, M. I. (2019). Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria. http://hdl.handle.net/11427/30665 | en_ZA |
| dc.identifier.chicagocitation | Ocheke, I. E, S. Mohamed, E. S Okpe, F. Bode-Thomas, and M. I McCullouch "Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria." (2019) http://hdl.handle.net/11427/30665 | en_ZA |
| dc.identifier.citation | Italian Journal of Pediatrics. 2019 Nov 12;45(1):143 | |
| dc.identifier.ris | TY - Journal Article AU - Ocheke, I. E AU - Mohamed, S. AU - Okpe, E. S AU - Bode-Thomas, F. AU - McCullouch, M. I AB - Abstract Introduction Evidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of kidney damage associated with SCA is microalbuminuria. Our objective was to determine the risk factors of microalbuminuria in these children and its relationship with estimated glomerular filtration rate. Methods This was a cross-sectional and comparative study involving three hundred and twenty three children with SCA in steady state and equal numbers of apparently healthy age and sex matched haemoglobin AA (HbAA) control, aged 6 months to 18 years. They were consecutively recruited over a 6 month period. Result Microalbuminuria was present in 26% of the study subjects compared with 1.85% of control P = 0.001). Anaemia and high estimated glomerular filtration rate (eGFR) showed strong positive correlation with microalbuminuria (OR = 3.19, CI 0.953–1.116, p = 0.003 and OR = 1.7, CI 1.042–1.066, p = 0.001 respectively). Similarly, eGFR was higher in subjects with SCA than in controls and as well as in those with microalbuminuria compared with those who do not (p = < 0.01). Conclusions The two most important risk factors for microalbuminuria were anaemia and high eGFR. Age category was associated more with microalbuminuria than just age as a variable. Glomerular filtration rate was higher in children with microalbuminuria than those who do not and it was also higher in children with SCA than in control. DA - 2019-11-12 DB - OpenUCT DP - University of Cape Town KW - Sickle cell anaemia KW - Children KW - Microalbuminuria KW - Risk KW - Estimated glomerular filtration rate LK - https://open.uct.ac.za PY - 2019 T1 - Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria TI - Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria UR - http://hdl.handle.net/11427/30665 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.1186/s13052-019-0720-0 | |
| dc.identifier.uri | http://hdl.handle.net/11427/30665 | |
| dc.identifier.vancouvercitation | Ocheke I E, Mohamed S, Okpe E S, Bode-Thomas F, McCullouch M I. Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria. 2019; http://hdl.handle.net/11427/30665. | en_ZA |
| dc.language.rfc3066 | en | |
| dc.rights.holder | The Author(s). | |
| dc.subject | Sickle cell anaemia | |
| dc.subject | Children | |
| dc.subject | Microalbuminuria | |
| dc.subject | Risk | |
| dc.subject | Estimated glomerular filtration rate | |
| dc.title | Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria | |
| dc.type | Journal Article |