Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry?

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dc.contributor.advisorMulder, Nicola
dc.contributor.advisorStein, Dan
dc.contributor.authorLabuschagne, Shelby Layla
dc.date.accessioned2026-04-22T07:02:18Z
dc.date.available2026-04-22T07:02:18Z
dc.date.issued2023
dc.date.updated2026-04-21T12:24:22Z
dc.description.abstractThis study aimed to determine whether the calculation of polygenic risk scores (PRS) could indicate a genetic link between gambling and alcohol use disorder. The main objective of the study was to determine if PRS for alcohol dependence in one study (NESARC dataset) could be used to predict the presence of gambling disorder in another (Alcohol Dependence dataset). No prior published research was found which calculates PRS for a substance addiction and applies it to the prediction of a behavioural addiction. The software PRSice was used to generate the PRS for two datasets, and these were analysed using linear modelling to determine whether the PRS for alcohol dependence (in the NESARC GWAS dataset) could predict the presence of GD in individuals with alcohol dependence. The model indicated accurate linkage 4.79% of the time. Due to this low percentage, it was concluded that PRS for alcohol dependence cannot accurately and regularly predict the presence of gambling disorder in individuals of European and African ancestry. However, we recognize limitations of the study, for example in the small sample size.
dc.identifier.apacitationLabuschagne, S. L. (2023). <i>Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry?</i>. (). University of Cape Town ,Faculty of Science ,Department of Biological Sciences. Retrieved from http://hdl.handle.net/11427/43108en_ZA
dc.identifier.chicagocitationLabuschagne, Shelby Layla. <i>"Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry?."</i> ., University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 2023. http://hdl.handle.net/11427/43108en_ZA
dc.identifier.citationLabuschagne, S.L. 2023. Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry?. . University of Cape Town ,Faculty of Science ,Department of Biological Sciences. http://hdl.handle.net/11427/43108en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Labuschagne, Shelby Layla AB - This study aimed to determine whether the calculation of polygenic risk scores (PRS) could indicate a genetic link between gambling and alcohol use disorder. The main objective of the study was to determine if PRS for alcohol dependence in one study (NESARC dataset) could be used to predict the presence of gambling disorder in another (Alcohol Dependence dataset). No prior published research was found which calculates PRS for a substance addiction and applies it to the prediction of a behavioural addiction. The software PRSice was used to generate the PRS for two datasets, and these were analysed using linear modelling to determine whether the PRS for alcohol dependence (in the NESARC GWAS dataset) could predict the presence of GD in individuals with alcohol dependence. The model indicated accurate linkage 4.79% of the time. Due to this low percentage, it was concluded that PRS for alcohol dependence cannot accurately and regularly predict the presence of gambling disorder in individuals of European and African ancestry. However, we recognize limitations of the study, for example in the small sample size. DA - 2023 DB - OpenUCT DP - University of Cape Town KW - Alcohol Dependence dataset KW - NESARC dataset KW - NESARC GWAS dataset LK - https://open.uct.ac.za PB - University of Cape Town PY - 2023 T1 - Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry? TI - Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry? UR - http://hdl.handle.net/11427/43108 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/43108
dc.identifier.vancouvercitationLabuschagne SL. Do polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry?. []. University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/43108en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Biological Sciences
dc.publisher.facultyFaculty of Science
dc.publisher.institutionUniversity of Cape Town
dc.subjectAlcohol Dependence dataset
dc.subjectNESARC dataset
dc.subjectNESARC GWAS dataset
dc.titleDo polygenic risk scores for alcohol dependence predict the presence of gambling disorder in individuals of European and African ancestry?
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMasters
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