The Role of the Eph Receptor Family in Tumorigenesis
| dc.contributor.author | Anderton, Meg | |
| dc.contributor.author | van der Meulen, Emma | |
| dc.contributor.author | Blumenthal, Melissa J | |
| dc.contributor.author | Schäfer, Georgia | |
| dc.date.accessioned | 2021-10-18T10:23:42Z | |
| dc.date.available | 2021-10-18T10:23:42Z | |
| dc.date.issued | 2021-01-08 | |
| dc.date.updated | 2021-01-22T15:47:48Z | |
| dc.description.abstract | The Eph receptor tyrosine kinase family, activated by binding to their cognate ephrin ligands, are important components of signalling pathways involved in animal development. More recently, they have received significant interest due to their involvement in oncogenesis. In most cases, their expression is altered, affecting the likes of cell proliferation and migration. Depending on the context, Eph receptors have the potential to act as both tumour promoters and suppressors in a number of cancers, such as breast cancer, colorectal cancer, lung cancer, prostate cancer, brain cancer and Kaposi’s sarcoma (KS), the latter being intrinsically linked to EphA2 as this is the receptor used for endothelial cell entry by the Kaposi’s sarcoma-associated herpesvirus (KSHV). In addition, EphA2 deregulation is associated with KS, indicating that it has a dual role in this case. Associations between EphA2 sequence variation and KSHV infection/KS progression have been detected, but further work is required to formally establish the links between EphA2 signalling and KS oncogenesis. This review consolidates the available literature of the role of the Eph receptor family, and particularly EphA2, in tumorigenesis, with the aim to develop a better understanding of Eph signalling pathways for potential targeting in novel cancer therapies. | en_US |
| dc.identifier | doi: 10.3390/cancers13020206 | |
| dc.identifier.apacitation | Anderton, M., van der Meulen, E., Blumenthal, M. J., & Schäfer, G. (2021). The Role of the Eph Receptor Family in Tumorigenesis. <i>Cancers</i>, 13(2), http://hdl.handle.net/11427/35264 | en_ZA |
| dc.identifier.chicagocitation | Anderton, Meg, Emma van der Meulen, Melissa J Blumenthal, and Georgia Schäfer "The Role of the Eph Receptor Family in Tumorigenesis." <i>Cancers</i> 13, 2. (2021) http://hdl.handle.net/11427/35264 | en_ZA |
| dc.identifier.citation | Anderton, M., van der Meulen, E., Blumenthal, M.J. & Schäfer, G. 2021. The Role of the Eph Receptor Family in Tumorigenesis. <i>Cancers.</i> 13(2) http://hdl.handle.net/11427/35264 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Anderton, Meg AU - van der Meulen, Emma AU - Blumenthal, Melissa J AU - Schäfer, Georgia AB - The Eph receptor tyrosine kinase family, activated by binding to their cognate ephrin ligands, are important components of signalling pathways involved in animal development. More recently, they have received significant interest due to their involvement in oncogenesis. In most cases, their expression is altered, affecting the likes of cell proliferation and migration. Depending on the context, Eph receptors have the potential to act as both tumour promoters and suppressors in a number of cancers, such as breast cancer, colorectal cancer, lung cancer, prostate cancer, brain cancer and Kaposi’s sarcoma (KS), the latter being intrinsically linked to EphA2 as this is the receptor used for endothelial cell entry by the Kaposi’s sarcoma-associated herpesvirus (KSHV). In addition, EphA2 deregulation is associated with KS, indicating that it has a dual role in this case. Associations between EphA2 sequence variation and KSHV infection/KS progression have been detected, but further work is required to formally establish the links between EphA2 signalling and KS oncogenesis. This review consolidates the available literature of the role of the Eph receptor family, and particularly EphA2, in tumorigenesis, with the aim to develop a better understanding of Eph signalling pathways for potential targeting in novel cancer therapies. DA - 2021-01-08 DB - OpenUCT DP - University of Cape Town IS - 2 J1 - Cancers KW - Eph receptors KW - EphA2 KW - Kaposi’s sarcoma KW - endothelial cells LK - https://open.uct.ac.za PY - 2021 T1 - The Role of the Eph Receptor Family in Tumorigenesis TI - The Role of the Eph Receptor Family in Tumorigenesis UR - http://hdl.handle.net/11427/35264 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.3390/cancers13020206 | |
| dc.identifier.uri | http://hdl.handle.net/11427/35264 | |
| dc.identifier.vancouvercitation | Anderton M, van der Meulen E, Blumenthal MJ, Schäfer G. The Role of the Eph Receptor Family in Tumorigenesis. Cancers. 2021;13(2) http://hdl.handle.net/11427/35264. | en_ZA |
| dc.language.iso | en | en_US |
| dc.publisher.department | Institute of Infectious Disease and Molecular Medicine | en_US |
| dc.publisher.faculty | Faculty of Health Sciences | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Cancers | en_US |
| dc.source.journalissue | 2 | en_US |
| dc.source.journalvolume | 13 | en_US |
| dc.source.uri | https://www.mdpi.com/journal/cancers | |
| dc.subject | Eph receptors | |
| dc.subject | EphA2 | |
| dc.subject | Kaposi’s sarcoma | |
| dc.subject | endothelial cells | |
| dc.title | The Role of the Eph Receptor Family in Tumorigenesis | en_US |
| dc.type | Journal Article | en_US |