The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study

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dc.contributor.advisorRamesar, Rajen_ZA
dc.contributor.advisorHorn, Neilen_ZA
dc.contributor.authorWeideman, Reinetteen_ZA
dc.date.accessioned2014-08-13T13:51:51Z
dc.date.available2014-08-13T13:51:51Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.descriptionName of degree provided by the Faculty of Health Sciences.en_ZA
dc.description.abstractLithium is regarded as the first-line pharmacotherapy for the treatment of acute mood episodes, suicide prevention and prophylactic treatment in patients with bipolar disorder (BPD). Response to lithium has a strong genetic component and lithium-responders have an increased frequency of BPD among their family members. Lithium has a narrow therapeutic index and 75-90% of patients on long-term lithium treatment experience one or more side effects, such as weight gain, cognitive decline and skin problems, amongst at least 20 side effects. The research project is immersed in a larger project on the genetics of bipolar disorder, in which a large number of individuals in families have been investigated over several years. The present pilot study explored whether single nucleotide polymorphisms (SNPs) within GSK3B, AKT1, ARRB2, GRIA2 and PPPARGC1A could be associated with the incidence and severity of lithium-induced side effects.en_ZA
dc.identifier.apacitationWeideman, R. (2013). <i>The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics. Retrieved from http://hdl.handle.net/11427/6091en_ZA
dc.identifier.chicagocitationWeideman, Reinette. <i>"The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics, 2013. http://hdl.handle.net/11427/6091en_ZA
dc.identifier.citationWeideman, R. 2013. The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Weideman, Reinette AB - Lithium is regarded as the first-line pharmacotherapy for the treatment of acute mood episodes, suicide prevention and prophylactic treatment in patients with bipolar disorder (BPD). Response to lithium has a strong genetic component and lithium-responders have an increased frequency of BPD among their family members. Lithium has a narrow therapeutic index and 75-90% of patients on long-term lithium treatment experience one or more side effects, such as weight gain, cognitive decline and skin problems, amongst at least 20 side effects. The research project is immersed in a larger project on the genetics of bipolar disorder, in which a large number of individuals in families have been investigated over several years. The present pilot study explored whether single nucleotide polymorphisms (SNPs) within GSK3B, AKT1, ARRB2, GRIA2 and PPPARGC1A could be associated with the incidence and severity of lithium-induced side effects. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study TI - The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study UR - http://hdl.handle.net/11427/6091 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6091
dc.identifier.vancouvercitationWeideman R. The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6091en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Human Geneticsen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleThe genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot studyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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