Evaluation of Membrane Permeability of Copper-Based Drugs
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2023-04-23
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Abstract
Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl<sub>2</sub> as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2 to 7. Octanol/water partition coefficients (log <i>K<sub>o/w</sub></i>) were measured and correlated with the permeability coefficients (<i>K<sub>p</sub></i>). In addition, chemical speciation was used to determine the predominant complex in solution at physiological pH. No correlation was found between the measured permeability coefficients and either molecular weight (MW) or log <i>K<sub>o/w</sub></i>.
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Inorganics 11 (5): 179 (2023)