Familial association of polycystic ovary syndrome (PCOS) in women attending the gynaecological endocrinology clinic at Groote Schuur Hospital

Master Thesis

2010

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http://hdl.handle.net/11427/10437
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thesis_hsf_2010_edelstein_s.pdf (1.36 MB)
Authors
Edelstein, Sascha
Supervisors
van der Spuy, Zephne Margaret
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University of Cape Town

Department
Department of Obstetrics and Gynaecology
Faculty
Faculty of Health Sciences
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Abstract
Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy in women of reproductive age, affecting 5-10% of women in the general population. Patients present with menstrual disturbances, infertility and clinical hyperandrogenism. While the pathophysiology is not completely delineated, a strong familial association has been demonstrated, suggesting a genetic component. From January 2007 until February 2009, a total of 83 probands were recruited from the Gynaecological Endocrinology Clinic (GEC) at GSH. These were all women with PCOS according to the Rotterdam criteria who presented for management at the GEC. With their consent, first degree female family members were contacted and 57 mothers, 108 sisters and 8 daughters agreed to participate in the study.
Description

Includes bibliographical references (leaves 60-65).

Keywords
Reproductive Medicine

Reference:

Edelstein, S. 2010. Familial association of polycystic ovary syndrome (PCOS) in women attending the gynaecological endocrinology clinic at Groote Schuur Hospital. University of Cape Town.

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