Proteomic analysis of the Mycobacterium avium-containing phagosome membrane

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dc.contributor.advisorThilo, Lutzen_ZA
dc.contributor.authorPietersen, Ray-Dean Donovanen_ZA
dc.date.accessioned2015-01-15T11:30:09Z
dc.date.available2015-01-15T11:30:09Z
dc.date.issued2010en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 139-158).en_ZA
dc.description.abstractPathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival.en_ZA
dc.identifier.apacitationPietersen, R. D. (2010). <i>Proteomic analysis of the Mycobacterium avium-containing phagosome membrane</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/12226en_ZA
dc.identifier.chicagocitationPietersen, Ray-Dean Donovan. <i>"Proteomic analysis of the Mycobacterium avium-containing phagosome membrane."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2010. http://hdl.handle.net/11427/12226en_ZA
dc.identifier.citationPietersen, R. 2010. Proteomic analysis of the Mycobacterium avium-containing phagosome membrane. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Pietersen, Ray-Dean Donovan AB - Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Proteomic analysis of the Mycobacterium avium-containing phagosome membrane TI - Proteomic analysis of the Mycobacterium avium-containing phagosome membrane UR - http://hdl.handle.net/11427/12226 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12226
dc.identifier.vancouvercitationPietersen RD. Proteomic analysis of the Mycobacterium avium-containing phagosome membrane. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12226en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleProteomic analysis of the Mycobacterium avium-containing phagosome membraneen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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