Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man

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dc.contributor.advisorForder, A Aen_ZA
dc.contributor.advisorDent, David Marshallen_ZA
dc.contributor.authorColdrey, Norman Aen_ZA
dc.date.accessioned2017-11-15T07:24:57Z
dc.date.available2017-11-15T07:24:57Z
dc.date.issued1987en_ZA
dc.date.updated2017-03-31T12:26:58Z
dc.description.abstractGastric aspirate specimens were collected from patients w~th clinically diagnosed gastric carcinoma and from non-carcinoma patients. The nitrite concentration and pH values of the aspirates were measured, the microorganisms present in selected specimens were isolated and identified, and the mutagenicity ratios of the aspirates were determined. The median nitrite concentration of the gastric aspirates from the carcinoma patients was significantly higher than that obtained for the non-carcinoma patients. A positive correlation was found between the nitrite concentration and the pH values of all the specimens tested, and a marked increase in nitrite levels at pH values above 6,0 was evident in specimens from the coloured ethnic "normal" subgroup. Gastric aspirate nitrite concentrations did not correlate with salivary values. The presence of microorganisms in gastric aspirates was shown to be pH dependent. Gastric aspirates with a pH < 2,0 were sterile, below pH 4,0 only acidophilic bacteria survived, whereas above pH 4,0, numerous species, predominantly members of the oral microflora, were isolated. The mean mutagenicity ratio of the gastric aspirates from the carcinoma patients was found to be significantly higher than that found for the control group. There was a positive correlation between the mutagenicity ratios of all the gastric specimens and pH with a maximum at a pH value of approximately 6,0.en_ZA
dc.identifier.apacitationColdrey, N. A. (1987). <i>Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology. Retrieved from http://hdl.handle.net/11427/26255en_ZA
dc.identifier.chicagocitationColdrey, Norman A. <i>"Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 1987. http://hdl.handle.net/11427/26255en_ZA
dc.identifier.citationColdrey, N. 1987. Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Coldrey, Norman A AB - Gastric aspirate specimens were collected from patients w~th clinically diagnosed gastric carcinoma and from non-carcinoma patients. The nitrite concentration and pH values of the aspirates were measured, the microorganisms present in selected specimens were isolated and identified, and the mutagenicity ratios of the aspirates were determined. The median nitrite concentration of the gastric aspirates from the carcinoma patients was significantly higher than that obtained for the non-carcinoma patients. A positive correlation was found between the nitrite concentration and the pH values of all the specimens tested, and a marked increase in nitrite levels at pH values above 6,0 was evident in specimens from the coloured ethnic "normal" subgroup. Gastric aspirate nitrite concentrations did not correlate with salivary values. The presence of microorganisms in gastric aspirates was shown to be pH dependent. Gastric aspirates with a pH &lt; 2,0 were sterile, below pH 4,0 only acidophilic bacteria survived, whereas above pH 4,0, numerous species, predominantly members of the oral microflora, were isolated. The mean mutagenicity ratio of the gastric aspirates from the carcinoma patients was found to be significantly higher than that found for the control group. There was a positive correlation between the mutagenicity ratios of all the gastric specimens and pH with a maximum at a pH value of approximately 6,0. DA - 1987 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1987 T1 - Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man TI - Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man UR - http://hdl.handle.net/11427/26255 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26255
dc.identifier.vancouvercitationColdrey NA. Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 1987 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26255en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherStomach - Canceren_ZA
dc.subject.otherMutagenicity testingen_ZA
dc.subject.otherBacteriaen_ZA
dc.subject.otherGastric juicesen_ZA
dc.subject.otherGastrointestinal neoplasms - etiologyen_ZA
dc.subject.otherMutagenicity testsen_ZA
dc.subject.otherNitritesen_ZA
dc.titleStudies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in manen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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