BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population

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dc.contributor.authorBrooks, Samantha Jen_ZA
dc.contributor.authorNilsson, Emil Ken_ZA
dc.contributor.authorJacobsson, Josefin Aen_ZA
dc.contributor.authorStein, Dan Jen_ZA
dc.contributor.authorFredriksson, Roberten_ZA
dc.contributor.authorLind, Larsen_ZA
dc.contributor.authorSchiöth, Helgi Ben_ZA
dc.date.accessioned2015-11-16T04:13:16Z
dc.date.available2015-11-16T04:13:16Z
dc.date.issued2014en_ZA
dc.description.abstractBACKGROUND: Brain-derived neurotrophic factor (BDNF) links learning, memory and cognitive decline in elderly, but evidence linking BDNF allele variation, cognition and brain structural differences is lacking. METHODS: 367 elderly Swedish men (n = 181) and women (n = 186) from Prospective Investigation of the Vasculature in Uppsala seniors (PIVUS) were genotyped and the BDNF functional rs6265 SNP was further examined in subjects who completed the Trail Making Task (TMT), verbal fluency task, and had a magnetic resonance imaging (MRI) scan. Voxel-based morphometry (VBM) examined brain structure, cognition and links with BDNF. RESULTS: The functional BDNF SNP (rs6265,) predicted better working memory performance on the TMT with positive association of the Met rs6265, and was linked with greater cerebellar, precuneus, left superior frontal gyrus and bilateral hippocampal volume, and reduced brainstem and bilateral posterior cingulate volumes. CONCLUSIONS: The functional BDNF polymorphism influences brain volume in regions associated with memory and regulation of sensorimotor control, with the Met rs6265 allele potentially being more beneficial to these functions in the elderly.en_ZA
dc.identifier.apacitationBrooks, S. J., Nilsson, E. K., Jacobsson, J. A., Stein, D. J., Fredriksson, R., Lind, L., & Schiöth, H. B. (2014). BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population. <i>PLoS One</i>, http://hdl.handle.net/11427/15027en_ZA
dc.identifier.chicagocitationBrooks, Samantha J, Emil K Nilsson, Josefin A Jacobsson, Dan J Stein, Robert Fredriksson, Lars Lind, and Helgi B Schiöth "BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population." <i>PLoS One</i> (2014) http://hdl.handle.net/11427/15027en_ZA
dc.identifier.citationBrooks, S. J., Nilsson, E. K., Jacobsson, J. A., Stein, D. J., Fredriksson, R., Lind, L., & Schiöth, H. B. (2014). BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population. PloS one, 9(1), e82707. doi:10.1371/journal.pone.0082707en_ZA
dc.identifier.ris TY - Journal Article AU - Brooks, Samantha J AU - Nilsson, Emil K AU - Jacobsson, Josefin A AU - Stein, Dan J AU - Fredriksson, Robert AU - Lind, Lars AU - Schiöth, Helgi B AB - BACKGROUND: Brain-derived neurotrophic factor (BDNF) links learning, memory and cognitive decline in elderly, but evidence linking BDNF allele variation, cognition and brain structural differences is lacking. METHODS: 367 elderly Swedish men (n = 181) and women (n = 186) from Prospective Investigation of the Vasculature in Uppsala seniors (PIVUS) were genotyped and the BDNF functional rs6265 SNP was further examined in subjects who completed the Trail Making Task (TMT), verbal fluency task, and had a magnetic resonance imaging (MRI) scan. Voxel-based morphometry (VBM) examined brain structure, cognition and links with BDNF. RESULTS: The functional BDNF SNP (rs6265,) predicted better working memory performance on the TMT with positive association of the Met rs6265, and was linked with greater cerebellar, precuneus, left superior frontal gyrus and bilateral hippocampal volume, and reduced brainstem and bilateral posterior cingulate volumes. CONCLUSIONS: The functional BDNF polymorphism influences brain volume in regions associated with memory and regulation of sensorimotor control, with the Met rs6265 allele potentially being more beneficial to these functions in the elderly. DA - 2014 DB - OpenUCT DO - 10.1371/journal.pone.0082707 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population TI - BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population UR - http://hdl.handle.net/11427/15027 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15027
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0082707
dc.identifier.vancouvercitationBrooks SJ, Nilsson EK, Jacobsson JA, Stein DJ, Fredriksson R, Lind L, et al. BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population. PLoS One. 2014; http://hdl.handle.net/11427/15027.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2014 Brooks et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherElderlyen_ZA
dc.subject.otherWorking memoryen_ZA
dc.subject.otherMemoryen_ZA
dc.subject.otherHippocampusen_ZA
dc.subject.otherRegression analysisen_ZA
dc.subject.otherAllelesen_ZA
dc.subject.otherCerebellumen_ZA
dc.subject.otherVoxel-based morphometryen_ZA
dc.titleBDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly populationen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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