Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans

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dc.contributor.authorTiffin, Nickien_ZA
dc.contributor.authorMeintjes, Aytonen_ZA
dc.contributor.authorRamesar, Rajkumaren_ZA
dc.contributor.authorBajic, Vladimir B.en_ZA
dc.contributor.authorRayner, Brianen_ZA
dc.date.accessioned2015-11-09T13:17:09Z
dc.date.available2015-11-09T13:17:09Z
dc.date.issued2010en_ZA
dc.description.abstractMultiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor ( PTH ) and type-1angiotensin II receptor ( AGTR1 ). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension.en_ZA
dc.identifier.apacitationTiffin, N., Meintjes, A., Ramesar, R., Bajic, Vladimir B., & Rayner, B. (2010). Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans. <i>PLoS One</i>, http://hdl.handle.net/11427/14782en_ZA
dc.identifier.chicagocitationTiffin, Nicki, Ayton Meintjes, Rajkumar Ramesar, Vladimir B. Bajic, and Brian Rayner "Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans." <i>PLoS One</i> (2010) http://hdl.handle.net/11427/14782en_ZA
dc.identifier.citationTiffin, N., Meintjes, A., Ramesar, R., Bajic, V. B., & Rayner, B. (2010). Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans. PloS one, 5(9). doi:10.1371/journal.pone.0012989en_ZA
dc.identifier.ris TY - Journal Article AU - Tiffin, Nicki AU - Meintjes, Ayton AU - Ramesar, Rajkumar AU - Bajic, Vladimir B. AU - Rayner, Brian AB - Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor ( PTH ) and type-1angiotensin II receptor ( AGTR1 ). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension. DA - 2010 DB - OpenUCT DO - 10.1371/journal.pone.0012989 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans TI - Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans UR - http://hdl.handle.net/11427/14782 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14782
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0012989
dc.identifier.vancouvercitationTiffin N, Meintjes A, Ramesar R, Bajic Vladimir B, Rayner B. Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans. PLoS One. 2010; http://hdl.handle.net/11427/14782.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Nephrology and Hypertensionen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2010 Tiffin et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHypertensionen_ZA
dc.subject.otherGene ontologiesen_ZA
dc.subject.otherAfricansen_ZA
dc.subject.otherBlood pressureen_ZA
dc.subject.otherKidneysen_ZA
dc.subject.otherCopy number variationen_ZA
dc.subject.otherParathyroid hormoneen_ZA
dc.subject.otherSodium channelsen_ZA
dc.titleComputational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africansen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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