The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

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dc.contributor.advisorSewell, Bryan Trevoren_ZA
dc.contributor.advisorSturrock, E Den_ZA
dc.contributor.authorChitapi, Itaien_ZA
dc.date.accessioned2014-07-30T17:36:13Z
dc.date.available2014-07-30T17:36:13Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractAngiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure.en_ZA
dc.identifier.apacitationChitapi, I. (2006). <i>The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/4248en_ZA
dc.identifier.chicagocitationChitapi, Itai. <i>"The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2006. http://hdl.handle.net/11427/4248en_ZA
dc.identifier.citationChitapi, I. 2006. The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Chitapi, Itai AB - Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 TI - The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 UR - http://hdl.handle.net/11427/4248 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/4248
dc.identifier.vancouvercitationChitapi I. The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/4248en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherStructural Biologyen_ZA
dc.titleThe structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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