A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population

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dc.contributor.advisorParkes, Jeannetteen_ZA
dc.contributor.authorHart, Heideen_ZA
dc.date.accessioned2017-01-26T13:33:44Z
dc.date.available2017-01-26T13:33:44Z
dc.date.issued2016en_ZA
dc.description.abstractBackground: Predictive factors for long-term outcomes in osteosarcoma patients are still controversial. There is no literature available regarding these factors in a patient population in a developing country. Objectives: To determine the outcome of treatment of osteosarcoma patients treated at Groote Schuur Hospital from 1990-2012 in terms of local control (LRC), disease free survival (DFS) and overall survival (OS) and to determine the value of suggested predictive factors in this population. Patients and methods: Retrospective review of all patients diagnosed and treated with osteosarcoma at Groote Schuur Hospital between 1990 and 2012, considering OS, DFS and LC. This review assesses the significance of suggested predictive factors from other studies, namely, HIV status, age at diagnosis, site of primary disease, type of chemotherapy used, response to chemotherapy and type of surgery in terms of OS, DFS and LC. Results: Forty-three patients with histologically confirmed osteosarcoma were treated at Groote Schuur Hospital between 1990 and 2012. Median 5 year OS was 57.8%. On univariate analysis, the site of disease was the only statistically significant predictive factor for prognosis. Conclusion: On univariate analysis, patients with axial disease have a worse predicted prognosis than those with primary disease in their extremities. The long-term outcome in our local clinical setting correlates favourably with the available international data. Due to the limited number of patients in the review, further research into HIV status, age, type of chemotherapy, type of surgery and their predictive value for prognosis in our patients with osteosarcoma is warranted.en_ZA
dc.identifier.apacitationHart, H. (2016). <i>A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Radiology. Retrieved from http://hdl.handle.net/11427/23396en_ZA
dc.identifier.chicagocitationHart, Heide. <i>"A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2016. http://hdl.handle.net/11427/23396en_ZA
dc.identifier.citationHart, H. 2016. A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hart, Heide AB - Background: Predictive factors for long-term outcomes in osteosarcoma patients are still controversial. There is no literature available regarding these factors in a patient population in a developing country. Objectives: To determine the outcome of treatment of osteosarcoma patients treated at Groote Schuur Hospital from 1990-2012 in terms of local control (LRC), disease free survival (DFS) and overall survival (OS) and to determine the value of suggested predictive factors in this population. Patients and methods: Retrospective review of all patients diagnosed and treated with osteosarcoma at Groote Schuur Hospital between 1990 and 2012, considering OS, DFS and LC. This review assesses the significance of suggested predictive factors from other studies, namely, HIV status, age at diagnosis, site of primary disease, type of chemotherapy used, response to chemotherapy and type of surgery in terms of OS, DFS and LC. Results: Forty-three patients with histologically confirmed osteosarcoma were treated at Groote Schuur Hospital between 1990 and 2012. Median 5 year OS was 57.8%. On univariate analysis, the site of disease was the only statistically significant predictive factor for prognosis. Conclusion: On univariate analysis, patients with axial disease have a worse predicted prognosis than those with primary disease in their extremities. The long-term outcome in our local clinical setting correlates favourably with the available international data. Due to the limited number of patients in the review, further research into HIV status, age, type of chemotherapy, type of surgery and their predictive value for prognosis in our patients with osteosarcoma is warranted. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population TI - A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population UR - http://hdl.handle.net/11427/23396 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/23396
dc.identifier.vancouvercitationHart H. A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/23396en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Radiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherRadiation Oncologyen_ZA
dc.titleA retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient populationen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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