A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus

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dc.contributor.authorTiffin, Nickien_ZA
dc.contributor.authorAdeyemo, Adebowaleen_ZA
dc.contributor.authorOkpechi, Ikechien_ZA
dc.date.accessioned2015-10-30T09:27:34Z
dc.date.available2015-10-30T09:27:34Z
dc.date.issued2013en_ZA
dc.description.abstractSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described.en_ZA
dc.identifier.apacitationTiffin, N., Adeyemo, A., & Okpechi, I. (2013). A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus. <i>Orphanet Journal of Rare Diseases</i>, http://hdl.handle.net/11427/14499en_ZA
dc.identifier.chicagocitationTiffin, Nicki, Adebowale Adeyemo, and Ikechi Okpechi "A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus." <i>Orphanet Journal of Rare Diseases</i> (2013) http://hdl.handle.net/11427/14499en_ZA
dc.identifier.citationTiffin, N., Adeyemo, A., & Okpechi, I. (2013). A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus. Orphanet J Rare Dis, 8(2).en_ZA
dc.identifier.ris TY - Journal Article AU - Tiffin, Nicki AU - Adeyemo, Adebowale AU - Okpechi, Ikechi AB - Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described. DA - 2013 DB - OpenUCT DO - 10.1186/1750-1172-8-2 DP - University of Cape Town J1 - Orphanet Journal of Rare Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus TI - A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus UR - http://hdl.handle.net/11427/14499 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14499
dc.identifier.urihttp://dx.doi.org/10.1186/1750-1172-8-2
dc.identifier.vancouvercitationTiffin N, Adeyemo A, Okpechi I. A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus. Orphanet Journal of Rare Diseases. 2013; http://hdl.handle.net/11427/14499.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Nephrology and Hypertensionen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2013 Tiffin et al.; licensee BioMed Central Ltden_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceOrphanet Journal of Rare Diseasesen_ZA
dc.source.urihttp://www.ojrd.com/en_ZA
dc.subject.otherSystemic lupus erythematosusen_ZA
dc.subject.otherAutoimmunityen_ZA
dc.subject.otherGenetic susceptibilityen_ZA
dc.subject.otherApoptosisen_ZA
dc.subject.otherdsDNAen_ZA
dc.subject.otherDisease genesen_ZA
dc.titleA diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosusen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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