Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorWatermeyer, Nicholas Den_ZA
dc.date.accessioned2014-08-13T14:25:31Z
dc.date.available2014-08-13T14:25:31Z
dc.date.issued2008en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractChloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains.en_ZA
dc.identifier.apacitationWatermeyer, N. D. (2008). <i>Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6283en_ZA
dc.identifier.chicagocitationWatermeyer, Nicholas D. <i>"Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008. http://hdl.handle.net/11427/6283en_ZA
dc.identifier.citationWatermeyer, N. 2008. Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Watermeyer, Nicholas D AB - Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents TI - Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents UR - http://hdl.handle.net/11427/6283 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6283
dc.identifier.vancouvercitationWatermeyer ND. Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6283en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleBioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agentsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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