Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen.

Simple item page
dc.contributor.authorVarsani, Arvind
dc.contributor.authorShepherd, Dionne N
dc.contributor.authorMonjane, Ade´rito L
dc.contributor.authorOwor, Betty E
dc.contributor.authorErdmann, Julia B
dc.contributor.authorRybicki, Edward P
dc.contributor.authorPeterschmitt, Michel
dc.contributor.authorBriddon, Rob W
dc.contributor.authorMarkham, Peter G
dc.contributor.authorOluwafemi, Sunday
dc.contributor.authorWindram, Oliver P
dc.contributor.authorLefeuvre, Pierre
dc.contributor.authorLett, Jean-Michel
dc.contributor.authorMartin, Darren P
dc.date.accessioned2016-07-27T13:34:23Z
dc.date.available2016-07-27T13:34:23Z
dc.date.issued2008
dc.date.updated2016-07-27T13:29:49Z
dc.description.abstractMaize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize streak disease, ranks amongst the most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one of these – MSV-A – causes severe disease in maize. Due primarily to their not being an obvious threat to agriculture, very little is known about the ‘grass-adapted’ MSV strains, MSV-B, -C, -D and -E. Since comparing the genetic diversities, geographical distributions and natural host ranges of MSV-A with the other MSV strains could provide valuable information on the epidemiology, evolution and emergence of MSV-A, we carried out a phylogeographical analysis of MSVs found in uncultivated indigenous African grasses. Amongst the 83 new MSV genomes presented here, we report the discovery of six new MSV strains (MSV-F to -K). The non-random recombination breakpoint distributions detectable with these and other available mastrevirus sequences partially mirror those seen in begomoviruses, implying that the forces shaping these breakpoint patterns have been largely conserved since the earliest geminivirus ancestors. We present evidence that the ancestor of all MSV-A variants was the recombinant progeny of ancestral MSV-B and MSV-G/-F variants. While it remains unknown whether recombination influenced the emergence of MSV-A in maize, our discovery that MSV-A variants may both move between and become established in different regions of Africa with greater ease, and infect more grass species than other MSV strains, goes some way towards explaining why MSV-A is such a successful maize pathogen.en_ZA
dc.identifierhttp://dx.doi.org/10.1099/vir.0.2008/003590-0
dc.identifier.apacitationVarsani, A., Shepherd, D. N., , Owor, B. E., Erdmann, J. B., Rybicki, E. P., ... Martin, D. P. (2008). Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen. <i>Journal of General Virology</i>, http://hdl.handle.net/11427/20902en_ZA
dc.identifier.chicagocitationVarsani, Arvind, Dionne N Shepherd, , Betty E Owor, Julia B Erdmann, Edward P Rybicki, Michel Peterschmitt, et al "Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen." <i>Journal of General Virology</i> (2008) http://hdl.handle.net/11427/20902en_ZA
dc.identifier.citationVarsani, A., Shepherd, D. N., Monjane, A. L., Owor, B. E., Erdmann, J. B., Rybicki, E. P., ... & Windram, O. P. (2008). Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen. Journal of General Virology, 89(9), 2063-2074.en_ZA
dc.identifier.issn0022-1317en_ZA
dc.identifier.ris TY - Journal Article AU - Varsani, Arvind AU - Shepherd, Dionne N AU - Monjane, Ade´rito L AU - Owor, Betty E AU - Erdmann, Julia B AU - Rybicki, Edward P AU - Peterschmitt, Michel AU - Briddon, Rob W AU - Markham, Peter G AU - Oluwafemi, Sunday AU - Windram, Oliver P AU - Lefeuvre, Pierre AU - Lett, Jean-Michel AU - Martin, Darren P AB - Maize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize streak disease, ranks amongst the most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one of these – MSV-A – causes severe disease in maize. Due primarily to their not being an obvious threat to agriculture, very little is known about the ‘grass-adapted’ MSV strains, MSV-B, -C, -D and -E. Since comparing the genetic diversities, geographical distributions and natural host ranges of MSV-A with the other MSV strains could provide valuable information on the epidemiology, evolution and emergence of MSV-A, we carried out a phylogeographical analysis of MSVs found in uncultivated indigenous African grasses. Amongst the 83 new MSV genomes presented here, we report the discovery of six new MSV strains (MSV-F to -K). The non-random recombination breakpoint distributions detectable with these and other available mastrevirus sequences partially mirror those seen in begomoviruses, implying that the forces shaping these breakpoint patterns have been largely conserved since the earliest geminivirus ancestors. We present evidence that the ancestor of all MSV-A variants was the recombinant progeny of ancestral MSV-B and MSV-G/-F variants. While it remains unknown whether recombination influenced the emergence of MSV-A in maize, our discovery that MSV-A variants may both move between and become established in different regions of Africa with greater ease, and infect more grass species than other MSV strains, goes some way towards explaining why MSV-A is such a successful maize pathogen. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - Journal of General Virology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 SM - 0022-1317 T1 - Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen TI - Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen UR - http://hdl.handle.net/11427/20902 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20902
dc.identifier.urihttp://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.2008/003590-0
dc.identifier.vancouvercitationVarsani A, Shepherd DN, , Owor BE, Erdmann JB, Rybicki EP, et al. Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen. Journal of General Virology. 2008; http://hdl.handle.net/11427/20902.en_ZA
dc.languageengen_ZA
dc.publisherMicrobiology Societyen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceJournal of General Virologyen_ZA
dc.source.urihttp://jgv.microbiologyresearch.org/content/journal/jgv
dc.subject.othermaize streak virus
dc.subject.otheragricultural pathogen
dc.titleRecombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen.en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Varsani_Recombination_decreased_2008.pdf
Size:
1023.18 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles