Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder

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dc.contributor.authorWomersley, Jacqueline S
dc.contributor.authorMpeta, Bafokeng
dc.contributor.authorDimatelis, Jacqueline J
dc.contributor.authorKellaway, Lauriston A
dc.contributor.authorStein, Dan J
dc.contributor.authorRussell, Vivienne A
dc.date.accessioned2016-07-29T10:21:37Z
dc.date.available2016-07-29T10:21:37Z
dc.date.issued2016-06-17
dc.date.updated2016-06-17T18:03:08Z
dc.description.abstractBackground: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attentiondeficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague–Dawley comparator strains. Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague–Dawley strains but not in Wistar Kyoto rats. Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.en_ZA
dc.identifier.apacitationWomersley, J. S., Mpeta, B., Dimatelis, J. J., Kellaway, L. A., Stein, D. J., & Russell, V. A. (2016). Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. <i>Behavioral and Brain Functions</i>, http://hdl.handle.net/11427/21020en_ZA
dc.identifier.chicagocitationWomersley, Jacqueline S, Bafokeng Mpeta, Jacqueline J Dimatelis, Lauriston A Kellaway, Dan J Stein, and Vivienne A Russell "Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder." <i>Behavioral and Brain Functions</i> (2016) http://hdl.handle.net/11427/21020en_ZA
dc.identifier.citationWomersley, J. S., Mpeta, B., Dimatelis, J. J., Kellaway, L. A., Stein, D. J., & Russell, V. A. (2016). Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Behavioral and Brain Functions, 12(1), 18.en_ZA
dc.identifier.issn1744-9081en_ZA
dc.identifier.ris TY - Journal Article AU - Womersley, Jacqueline S AU - Mpeta, Bafokeng AU - Dimatelis, Jacqueline J AU - Kellaway, Lauriston A AU - Stein, Dan J AU - Russell, Vivienne A AB - Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attentiondeficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague–Dawley comparator strains. Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague–Dawley strains but not in Wistar Kyoto rats. Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders. DA - 2016-06-17 DB - OpenUCT DO - 10.1186/s12993-016-0102-3 DP - University of Cape Town J1 - Behavioral and Brain Functions LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 SM - 1744-9081 T1 - Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder TI - Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder UR - http://hdl.handle.net/11427/21020 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12993-016-0102-3
dc.identifier.urihttp://hdl.handle.net/11427/21020
dc.identifier.vancouvercitationWomersley JS, Mpeta B, Dimatelis JJ, Kellaway LA, Stein DJ, Russell VA. Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Behavioral and Brain Functions. 2016; http://hdl.handle.net/11427/21020.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceBehavioral and Brain Functionsen_ZA
dc.source.urihttps://behavioralandbrainfunctions.biomedcentral.com/
dc.titleDevelopmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorderen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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