The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study

Simple item page
dc.contributor.authorDhokotera, Tafadzwa
dc.contributor.authorBohlius, Julia
dc.contributor.authorSpoerri, Adrian
dc.contributor.authorEgger, Matthias
dc.contributor.authorNcayiyana, Jabulani
dc.contributor.authorOlago, Victor
dc.contributor.authorSingh, Elvira
dc.contributor.authorSengayi, Mazvita
dc.date.accessioned2019-06-20T09:20:29Z
dc.date.available2019-06-20T09:20:29Z
dc.date.issued2019-05-03
dc.date.updated2019-05-05T03:34:35Z
dc.description.abstractAbstract Introduction The impact of South Africa’s high human immunodeficiency virus (HIV) burden on cancer risk is not fully understood, particularly in the context of antiretroviral treatment (ART) availability. We examined national cancer trends and excess cancer risk in people living with HIV (PLHIV) compared to those who are HIV-negative. Methods We used probabilistic record linkage to match cancer records provided by the National Cancer Registry to HIV data provided by the National Health Laboratory Service (NHLS). We also used text search of specific HIV terms from the clinical section of pathology reports to determine HIV status of cancer patients. We used logistic and Joinpoint regression models to evaluate the risk and trends in cancers in PLHIV compared to HIV-negative patients from 2004 to 2014. In sensitivity analysis, we used inverse probability weighting (IPW) to correct for possible selection bias. Results A total of 329,208 cancer cases from public sector laboratories were reported to the NCR from 2004 to 2014 with the HIV status known for 95,279 (28.9%) cancer cases. About 50% of all the female cancer cases (n = 30,486) with a known status were HIV-positive. PLHIV were at higher risk of AIDS-defining cancers (Kaposi sarcoma [adjusted OR:134, 95% CI:111–162], non-Hodgkin lymphoma [adjusted OR:2.73, 95% CI:2.56–2.91] and, cervix [adjusted OR:1.70, 95% CI:1.63–1.77], conjunctival cancer [adjusted OR:21.5, 95% CI:16.3–28.4] and human papilloma virus (HPV) related cancers (including; penis [adjusted OR:2.35, 95% CI:1.85–2.99], and vulva [adjusted OR:1.94, 95% CI:1.67–2.25]) compared to HIV-negative patients. Analysis using the IPW population yielded comparable results. Conclusion There is need for improved awareness and screening of conjunctival cancer and HPV-associated cancers at HIV care centres. Further research and discussion is warranted on inclusive HPV vaccination in PLHIV.
dc.identifier.apacitationDhokotera, T., Bohlius, J., Spoerri, A., Egger, M., Ncayiyana, J., Olago, V., ... Sengayi, M. (2019). The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study. <i>Infectious Agents and Cancer</i>, http://hdl.handle.net/11427/30225en_ZA
dc.identifier.chicagocitationDhokotera, Tafadzwa, Julia Bohlius, Adrian Spoerri, Matthias Egger, Jabulani Ncayiyana, Victor Olago, Elvira Singh, and Mazvita Sengayi "The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study." <i>Infectious Agents and Cancer</i> (2019) http://hdl.handle.net/11427/30225en_ZA
dc.identifier.citationDhokotera, T., Bohlius, J., Spoerri, A., Egger, M., Ncayiyana, J., Olago, V., ... & Sengayi, M. 2019. The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study. Infectious agents and cancer, 14(1): 12.
dc.identifier.ris TY - AU - Dhokotera, Tafadzwa AU - Bohlius, Julia AU - Spoerri, Adrian AU - Egger, Matthias AU - Ncayiyana, Jabulani AU - Olago, Victor AU - Singh, Elvira AU - Sengayi, Mazvita AB - Abstract Introduction The impact of South Africa’s high human immunodeficiency virus (HIV) burden on cancer risk is not fully understood, particularly in the context of antiretroviral treatment (ART) availability. We examined national cancer trends and excess cancer risk in people living with HIV (PLHIV) compared to those who are HIV-negative. Methods We used probabilistic record linkage to match cancer records provided by the National Cancer Registry to HIV data provided by the National Health Laboratory Service (NHLS). We also used text search of specific HIV terms from the clinical section of pathology reports to determine HIV status of cancer patients. We used logistic and Joinpoint regression models to evaluate the risk and trends in cancers in PLHIV compared to HIV-negative patients from 2004 to 2014. In sensitivity analysis, we used inverse probability weighting (IPW) to correct for possible selection bias. Results A total of 329,208 cancer cases from public sector laboratories were reported to the NCR from 2004 to 2014 with the HIV status known for 95,279 (28.9%) cancer cases. About 50% of all the female cancer cases (n = 30,486) with a known status were HIV-positive. PLHIV were at higher risk of AIDS-defining cancers (Kaposi sarcoma [adjusted OR:134, 95% CI:111–162], non-Hodgkin lymphoma [adjusted OR:2.73, 95% CI:2.56–2.91] and, cervix [adjusted OR:1.70, 95% CI:1.63–1.77], conjunctival cancer [adjusted OR:21.5, 95% CI:16.3–28.4] and human papilloma virus (HPV) related cancers (including; penis [adjusted OR:2.35, 95% CI:1.85–2.99], and vulva [adjusted OR:1.94, 95% CI:1.67–2.25]) compared to HIV-negative patients. Analysis using the IPW population yielded comparable results. Conclusion There is need for improved awareness and screening of conjunctival cancer and HPV-associated cancers at HIV care centres. Further research and discussion is warranted on inclusive HPV vaccination in PLHIV. DA - 2019-05-03 DB - OpenUCT DP - University of Cape Town J1 - Infectious Agents and Cancer KW - HIV and cancer KW - Epidemiology KW - South Africa KW - Antiretroviral era KW - Cancer risk LK - https://open.uct.ac.za PY - 2019 T1 - The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study TI - The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study UR - http://hdl.handle.net/11427/30225 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13027-019-0228-7
dc.identifier.urihttp://hdl.handle.net/11427/30225
dc.identifier.vancouvercitationDhokotera T, Bohlius J, Spoerri A, Egger M, Ncayiyana J, Olago V, et al. The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study. Infectious Agents and Cancer. 2019; http://hdl.handle.net/11427/30225.en_ZA
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.sourceInfectious Agents and Cancer
dc.source.urihttps://infectagentscancer.biomedcentral.com/
dc.subjectHIV and cancer
dc.subjectEpidemiology
dc.subjectSouth Africa
dc.subjectAntiretroviral era
dc.subjectCancer risk
dc.titleThe burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage study
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Dhokotera et al_2019_Article.pdf
Size:
1.13 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles