Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction

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dc.contributor.advisorSewell, Trevoren_ZA
dc.contributor.authorPatel, Satishkumar Ishverlalen_ZA
dc.date.accessioned2016-03-03T14:46:28Z
dc.date.available2016-03-03T14:46:28Z
dc.date.issued2015en_ZA
dc.descriptionIncludes bibliographical referencesen_ZA
dc.description.abstract[No subject] Malaria infection caused by the apicomplexa pathogen Plasmodium falciparum has a high rate of resistance to existing anti-malarial drugs. The World Health Organisation recommended interventions are unlikely to eliminate the growth of resistance and it would therefore be prudent to continue the search for new drug targets for the continued combatting of malaria. Plasmodium falciparum is parasitic on the host for its metabolites and therefore inhibiting the transportation of glutamine from the host, has long been considered a potential strategy for combating the spread of infection. The recently sequenced Plasmodium falciparum genome has however shown that pathways for independent survival are also conserved. Therefore, combating the spread of Plasmodium falciparum in the human host, in addition to inhibiting the transportation of glutamine, will also require the inhibition of the de novo expression of essential amino acids within the Plasmodium falciparum cell. This could be achieved by inhibiting the glutamine synthetase gene, which is an essential step in the tri-carboxylic acid cycle.en_ZA
dc.identifier.apacitationPatel, S. I. (2015). <i>Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/17429en_ZA
dc.identifier.chicagocitationPatel, Satishkumar Ishverlal. <i>"Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2015. http://hdl.handle.net/11427/17429en_ZA
dc.identifier.citationPatel, S. 2015. Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Patel, Satishkumar Ishverlal AB - [No subject] Malaria infection caused by the apicomplexa pathogen Plasmodium falciparum has a high rate of resistance to existing anti-malarial drugs. The World Health Organisation recommended interventions are unlikely to eliminate the growth of resistance and it would therefore be prudent to continue the search for new drug targets for the continued combatting of malaria. Plasmodium falciparum is parasitic on the host for its metabolites and therefore inhibiting the transportation of glutamine from the host, has long been considered a potential strategy for combating the spread of infection. The recently sequenced Plasmodium falciparum genome has however shown that pathways for independent survival are also conserved. Therefore, combating the spread of Plasmodium falciparum in the human host, in addition to inhibiting the transportation of glutamine, will also require the inhibition of the de novo expression of essential amino acids within the Plasmodium falciparum cell. This could be achieved by inhibiting the glutamine synthetase gene, which is an essential step in the tri-carboxylic acid cycle. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction TI - Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction UR - http://hdl.handle.net/11427/17429 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/17429
dc.identifier.vancouvercitationPatel SI. Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17429en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMalariaen_ZA
dc.subject.otherPlasmodium falciparumen_ZA
dc.titleSoluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstructionen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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