Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights
| dc.contributor.author | Coleman, Mikaela | |
| dc.contributor.author | Martinez, Leonardo | |
| dc.contributor.author | Theron, Grant | |
| dc.contributor.author | Wood, Robin | |
| dc.contributor.author | Marais, Ben | |
| dc.date.accessioned | 2024-04-29T10:29:50Z | |
| dc.date.available | 2024-04-29T10:29:50Z | |
| dc.date.issued | 2022-10-25 | |
| dc.date.updated | 2022-11-24T14:43:22Z | |
| dc.description.abstract | Tuberculosis has affected humankind for thousands of years, but a deeper understanding of its cause and transmission only arose after Robert Koch discovered <i>Mycobacterium tuberculosis</i> in 1882. Valuable insight has been gained since, but the accumulation of knowledge has been frustratingly slow and incomplete for a pathogen that remains the number one infectious disease killer on the planet. Contrast that to the rapid progress that has been made in our understanding SARS-CoV-2 (the cause of COVID-19) aerobiology and transmission. In this Review, we discuss important historical and contemporary insights into <i>M. tuberculosis</i> transmission. Historical insights describing the principles of aerosol transmission, as well as relevant pathogen, host and environment factors are described. Furthermore, novel insights into asymptomatic and subclinical tuberculosis, and the potential role this may play in population-level transmission is discussed. Progress towards understanding the full spectrum of <i>M. tuberculosis</i> transmission in high-burden settings has been hampered by sub-optimal diagnostic tools, limited basic science exploration and inadequate study designs. We propose that, as a tuberculosis field, we must learn from and capitalize on the novel insights and methods that have been developed to investigate SARS-CoV-2 transmission to limit ongoing tuberculosis transmission, which sustains the global pandemic. | |
| dc.identifier | doi: 10.3390/pathogens11111228 | |
| dc.identifier.apacitation | Coleman, M., Martinez, L., Theron, G., Wood, R., & Marais, B. (2022). Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights. http://hdl.handle.net/11427/39481 | en_ZA |
| dc.identifier.chicagocitation | Coleman, Mikaela, Leonardo Martinez, Grant Theron, Robin Wood, and Ben Marais "Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights." (2022) http://hdl.handle.net/11427/39481 | en_ZA |
| dc.identifier.citation | Pathogens 11 (11): 1228 (2022) | |
| dc.identifier.ris | TY - Journal Article AU - Coleman, Mikaela AU - Martinez, Leonardo AU - Theron, Grant AU - Wood, Robin AU - Marais, Ben AB - Tuberculosis has affected humankind for thousands of years, but a deeper understanding of its cause and transmission only arose after Robert Koch discovered <i>Mycobacterium tuberculosis</i> in 1882. Valuable insight has been gained since, but the accumulation of knowledge has been frustratingly slow and incomplete for a pathogen that remains the number one infectious disease killer on the planet. Contrast that to the rapid progress that has been made in our understanding SARS-CoV-2 (the cause of COVID-19) aerobiology and transmission. In this Review, we discuss important historical and contemporary insights into <i>M. tuberculosis</i> transmission. Historical insights describing the principles of aerosol transmission, as well as relevant pathogen, host and environment factors are described. Furthermore, novel insights into asymptomatic and subclinical tuberculosis, and the potential role this may play in population-level transmission is discussed. Progress towards understanding the full spectrum of <i>M. tuberculosis</i> transmission in high-burden settings has been hampered by sub-optimal diagnostic tools, limited basic science exploration and inadequate study designs. We propose that, as a tuberculosis field, we must learn from and capitalize on the novel insights and methods that have been developed to investigate SARS-CoV-2 transmission to limit ongoing tuberculosis transmission, which sustains the global pandemic. DA - 2022-10-25 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PY - 2022 T1 - Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights TI - Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights UR - http://hdl.handle.net/11427/39481 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/39481 | |
| dc.identifier.vancouvercitation | Coleman M, Martinez L, Theron G, Wood R, Marais B. Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights. 2022; http://hdl.handle.net/11427/39481. | en_ZA |
| dc.title | Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights | |
| dc.type | Journal Article |