Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression

dc.contributor.authorKader, Rehanaen_ZA
dc.contributor.authorGovender, Rajenen_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.contributor.authorKoch, John Randyen_ZA
dc.contributor.authorParry, Charlesen_ZA
dc.date.accessioned2015-12-28T06:48:47Z
dc.date.available2015-12-28T06:48:47Z
dc.date.issued2015en_ZA
dc.description.abstractThe objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA.en_ZA
dc.identifier.apacitationKader, R., Govender, R., Seedat, S., Koch, J. R., & Parry, C. (2015). Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. <i>PLoS One</i>, http://hdl.handle.net/11427/16058en_ZA
dc.identifier.chicagocitationKader, Rehana, Rajen Govender, Soraya Seedat, John Randy Koch, and Charles Parry "Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression." <i>PLoS One</i> (2015) http://hdl.handle.net/11427/16058en_ZA
dc.identifier.citationKader, R., Govender, R., Seedat, S., Koch, J. R., & Parry, C. (2014). Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. PloS one, 10(5), e0125088. doi:10.1371/journal.pone.0125088en_ZA
dc.identifier.ris TY - Journal Article AU - Kader, Rehana AU - Govender, Rajen AU - Seedat, Soraya AU - Koch, John Randy AU - Parry, Charles AB - The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA. DA - 2015 DB - OpenUCT DO - 10.1371/journal.pone.0125088 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression TI - Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression UR - http://hdl.handle.net/11427/16058 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16058
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0125088
dc.identifier.vancouvercitationKader R, Govender R, Seedat S, Koch JR, Parry C. Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. PLoS One. 2015; http://hdl.handle.net/11427/16058.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentSocial Anthropologyen_ZA
dc.publisher.facultyFaculty of Humanitiesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2015 Kader et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherAlcoholismen_ZA
dc.subject.otherAlcohol consumptionen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherSubstance abuseen_ZA
dc.subject.otherDrug adherenceen_ZA
dc.subject.otherDrug usersen_ZA
dc.subject.otherDrug abuseen_ZA
dc.subject.otherSouth Africaen_ZA
dc.titleUnderstanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progressionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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