An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis

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dc.contributor.advisorMulder, Nicolaen_ZA
dc.contributor.authorOpap, Kenneth Babuen_ZA
dc.date.accessioned2015-01-03T05:29:18Z
dc.date.available2015-01-03T05:29:18Z
dc.date.issued2011en_ZA
dc.descriptionIncludes bibliographical references (leaves 96-103).en_ZA
dc.description.abstractProteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression).en_ZA
dc.identifier.apacitationOpap, K. B. (2011). <i>An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/11086en_ZA
dc.identifier.chicagocitationOpap, Kenneth Babu. <i>"An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2011. http://hdl.handle.net/11427/11086en_ZA
dc.identifier.citationOpap, K. 2011. An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Opap, Kenneth Babu AB - Proteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression). DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis TI - An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis UR - http://hdl.handle.net/11427/11086 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11086
dc.identifier.vancouvercitationOpap KB. An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11086en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleAn integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosisen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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