Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles
| dc.contributor.author | Tukulula, Matshawandile | |
| dc.contributor.author | Louw, Stefan | |
| dc.contributor.author | Njoroge, Mathew | |
| dc.contributor.author | Chibale, Kelly | |
| dc.date.accessioned | 2021-10-13T18:32:06Z | |
| dc.date.available | 2021-10-13T18:32:06Z | |
| dc.date.issued | 2020-12-15 | |
| dc.date.updated | 2020-12-24T20:36:42Z | |
| dc.description.abstract | A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential antiplasmodium activity against a multidrug-resistant K1 strain and for their antitrypanosomal activity against a cultured T. b. rhodesiense STIB900 strain. Several of these compounds (4a–g) displayed good antiplasmodium activities (IC50 = 0.20–0.62 µM) that were comparable to the reference drugs, while their antitrypanosomal activity was moderate (200 µM) at pH 7. | en_US |
| dc.identifier | doi: 10.3390/molecules25245941 | |
| dc.identifier.apacitation | Tukulula, M., Louw, S., Njoroge, M., & Chibale, K. (2020). Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles. <i>Molecules</i>, 25(24), http://hdl.handle.net/11427/35234 | en_ZA |
| dc.identifier.chicagocitation | Tukulula, Matshawandile, Stefan Louw, Mathew Njoroge, and Kelly Chibale "Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles." <i>Molecules</i> 25, 24. (2020) http://hdl.handle.net/11427/35234 | en_ZA |
| dc.identifier.citation | Tukulula, M., Louw, S., Njoroge, M. & Chibale, K. 2020. Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles. <i>Molecules.</i> 25(24) http://hdl.handle.net/11427/35234 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Tukulula, Matshawandile AU - Louw, Stefan AU - Njoroge, Mathew AU - Chibale, Kelly AB - A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential antiplasmodium activity against a multidrug-resistant K1 strain and for their antitrypanosomal activity against a cultured T. b. rhodesiense STIB900 strain. Several of these compounds (4a–g) displayed good antiplasmodium activities (IC50 = 0.20–0.62 µM) that were comparable to the reference drugs, while their antitrypanosomal activity was moderate (200 µM) at pH 7. DA - 2020-12-15 DB - OpenUCT DP - University of Cape Town IS - 24 J1 - Molecules LK - https://open.uct.ac.za PY - 2020 T1 - Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles TI - Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles UR - http://hdl.handle.net/11427/35234 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.3390/molecules25245941 | |
| dc.identifier.uri | http://hdl.handle.net/11427/35234 | |
| dc.identifier.vancouvercitation | Tukulula M, Louw S, Njoroge M, Chibale K. Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles. Molecules. 2020;25(24) http://hdl.handle.net/11427/35234. | en_ZA |
| dc.publisher.department | Department of Chemistry | en_US |
| dc.publisher.faculty | Faculty of Science | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Molecules | en_US |
| dc.source.journalissue | 24 | en_US |
| dc.source.journalvolume | 25 | en_US |
| dc.source.uri | https://www.mdpi.com/journal/molecules | |
| dc.title | Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles | en_US |
| dc.type | Journal Article | en_US |