Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice

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dc.contributor.advisorRybicki, Eden_ZA
dc.contributor.advisorMeyers, Annen_ZA
dc.contributor.authorPillay, Sirikaen_ZA
dc.date.accessioned2014-07-30T17:41:38Z
dc.date.available2014-07-30T17:41:38Z
dc.date.issued2008en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (leaves 139-148).
dc.description.abstractThe devastating effect the HIV pandemic has had on the human population in the last twenty five years has highlighted the great need to develop a prophylactic HIV vaccine. The manufacture of a vaccine has proven difficult though, with a number of successful designs in animal models having little success in humans. In view of this, there has been a need for novel vaccine approaches that are able to elicit effective cellular and humoral immune responses, both of which are believed to be important in the eradication of the virus. One such approach is the use of HIV-1 Gag VLPs as vaccine candidates. In this study, the production of two chimaeric (Gag VLP vaccine candidates (GagRT and GagTN) was optimized in insect cells, and their ability to enhance a murine immune response in a DNA prime-VLP boost vaccine strategy was evaluated.en_ZA
dc.identifier.apacitationPillay, S. (2008). <i>Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/4321en_ZA
dc.identifier.chicagocitationPillay, Sirika. <i>"Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2008. http://hdl.handle.net/11427/4321en_ZA
dc.identifier.citationPillay, S. 2008. Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Pillay, Sirika AB - The devastating effect the HIV pandemic has had on the human population in the last twenty five years has highlighted the great need to develop a prophylactic HIV vaccine. The manufacture of a vaccine has proven difficult though, with a number of successful designs in animal models having little success in humans. In view of this, there has been a need for novel vaccine approaches that are able to elicit effective cellular and humoral immune responses, both of which are believed to be important in the eradication of the virus. One such approach is the use of HIV-1 Gag VLPs as vaccine candidates. In this study, the production of two chimaeric (Gag VLP vaccine candidates (GagRT and GagTN) was optimized in insect cells, and their ability to enhance a murine immune response in a DNA prime-VLP boost vaccine strategy was evaluated. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice TI - Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice UR - http://hdl.handle.net/11427/4321 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/4321
dc.identifier.vancouvercitationPillay S. Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/4321en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleOptimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in miceen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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