Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study

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dc.contributor.authorLingappa, Jairam Ren_ZA
dc.contributor.authorKahle, Erinen_ZA
dc.contributor.authorMugo, Nellyen_ZA
dc.contributor.authorMujugira, Andrewen_ZA
dc.contributor.authorMagaret, Amaliaen_ZA
dc.contributor.authorBaeten, Jareden_ZA
dc.contributor.authorBukusi, Elizabeth Aen_ZA
dc.contributor.authorCohen, Craig Ren_ZA
dc.contributor.authorKatabira, Ellyen_ZA
dc.contributor.authorRonald, Allanen_ZA
dc.date.accessioned2016-01-02T05:05:41Z
dc.date.available2016-01-02T05:05:41Z
dc.date.issued2009en_ZA
dc.description.abstractBACKGROUND: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort. METHODS: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count ≥250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. RESULTS: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2-9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (<5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462cells/mcL and median HIV-1 plasma RNA was 4.2 log 10 copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+0.24 log 10 copies/mL; p<0.001) and CD4 count (−0.25 and −0.55 log 10 copies/mL for CD4 350-499 and >500 relative to <350, respectively, p<0.001). CONCLUSIONS: The Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission. Trial Registration ClinicalTrials.gov NCT00194519en_ZA
dc.identifier.apacitationLingappa, J. R., Kahle, E., Mugo, N., Mujugira, A., Magaret, A., Baeten, J., ... Ronald, A. (2009). Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study. <i>PLoS One</i>, http://hdl.handle.net/11427/16152en_ZA
dc.identifier.chicagocitationLingappa, Jairam R, Erin Kahle, Nelly Mugo, Andrew Mujugira, Amalia Magaret, Jared Baeten, Elizabeth A Bukusi, Craig R Cohen, Elly Katabira, and Allan Ronald "Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study." <i>PLoS One</i> (2009) http://hdl.handle.net/11427/16152en_ZA
dc.identifier.citationLingappa, J. R., Kahle, E., Mugo, N., Mujugira, A., Magaret, A., Baeten, J., ... & Kiarie, J. (2009). Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study. PloS one, 4(4), e5272. doi:10.1371/journal.pone.0005272en_ZA
dc.identifier.ris TY - Journal Article AU - Lingappa, Jairam R AU - Kahle, Erin AU - Mugo, Nelly AU - Mujugira, Andrew AU - Magaret, Amalia AU - Baeten, Jared AU - Bukusi, Elizabeth A AU - Cohen, Craig R AU - Katabira, Elly AU - Ronald, Allan AB - BACKGROUND: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort. METHODS: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count ≥250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. RESULTS: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2-9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (<5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462cells/mcL and median HIV-1 plasma RNA was 4.2 log 10 copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+0.24 log 10 copies/mL; p<0.001) and CD4 count (−0.25 and −0.55 log 10 copies/mL for CD4 350-499 and >500 relative to <350, respectively, p<0.001). CONCLUSIONS: The Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission. Trial Registration ClinicalTrials.gov NCT00194519 DA - 2009 DB - OpenUCT DO - 10.1371/journal.pone.0005272 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study TI - Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study UR - http://hdl.handle.net/11427/16152 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16152
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0005272
dc.identifier.vancouvercitationLingappa JR, Kahle E, Mugo N, Mujugira A, Magaret A, Baeten J, et al. Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study. PLoS One. 2009; http://hdl.handle.net/11427/16152.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2009 Lingappa et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherAfricaen_ZA
dc.subject.otherHerpes simplex virus-2en_ZA
dc.subject.otherSexually transmitted diseasesen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherTrichomonas vaginalisen_ZA
dc.subject.otherDemographyen_ZA
dc.subject.otherChlamydia trachomatisen_ZA
dc.titleCharacteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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