Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

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dc.contributor.authorDavis, Lea Ken_ZA
dc.contributor.authorYu, Dongmeien_ZA
dc.contributor.authorKeenan, Clare Len_ZA
dc.contributor.authorGamazon, Eric Ren_ZA
dc.contributor.authorKonkashbaev, Anuar Ien_ZA
dc.contributor.authorDerks, Eske Men_ZA
dc.contributor.authorNeale, Benjamin Men_ZA
dc.contributor.authorYang, Jianen_ZA
dc.contributor.authorLee, S Hongen_ZA
dc.contributor.authorEvans, Patricken_ZA
dc.date.accessioned2015-12-28T06:52:36Z
dc.date.available2015-12-28T06:52:36Z
dc.date.issued2013en_ZA
dc.description.abstractAuthor Summary Family and twin studies have shown that genetic risk factors are important in the development of Tourette Syndrome (TS) and obsessive compulsive disorder (OCD). However, efforts to identify the individual genetic risk factors involved in these two neuropsychiatric disorders have been largely unsuccessful. One possible explanation for this is that many genetic variations scattered throughout the genome each contribute a small amount to the overall risk. For TS and OCD, the genetic architecture (characterized by the number, frequency, and distribution of genetic risk factors) is presently unknown. This study examined the genetic architecture of TS and OCD in a variety of ways. We found that rare genetic changes account for more genetic risk in TS than in OCD; certain chromosomes contribute to OCD risk more than others; and variants that influence the level of genes expressed in two regions of the brain can account for a significant amount of risk for both TS and OCD. Results from this study might help in determining where, and what kind of variants are individual risk factors for TS and OCD and where they might be located in the human genome.en_ZA
dc.identifier.apacitationDavis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., ... Evans, P. (2013). Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. <i>PLOS Genetics</i>, http://hdl.handle.net/11427/16075en_ZA
dc.identifier.chicagocitationDavis, Lea K, Dongmei Yu, Clare L Keenan, Eric R Gamazon, Anuar I Konkashbaev, Eske M Derks, Benjamin M Neale, Jian Yang, S Hong Lee, and Patrick Evans "Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture." <i>PLOS Genetics</i> (2013) http://hdl.handle.net/11427/16075en_ZA
dc.identifier.citationDavis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., ... & Barr, C. L. (2013). Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 9(10): e1003864. doi: 10.1371/journal.pgen.1003864. doi:10.1371/journal.pgen.1003864en_ZA
dc.identifier.ris TY - Journal Article AU - Davis, Lea K AU - Yu, Dongmei AU - Keenan, Clare L AU - Gamazon, Eric R AU - Konkashbaev, Anuar I AU - Derks, Eske M AU - Neale, Benjamin M AU - Yang, Jian AU - Lee, S Hong AU - Evans, Patrick AB - Author Summary Family and twin studies have shown that genetic risk factors are important in the development of Tourette Syndrome (TS) and obsessive compulsive disorder (OCD). However, efforts to identify the individual genetic risk factors involved in these two neuropsychiatric disorders have been largely unsuccessful. One possible explanation for this is that many genetic variations scattered throughout the genome each contribute a small amount to the overall risk. For TS and OCD, the genetic architecture (characterized by the number, frequency, and distribution of genetic risk factors) is presently unknown. This study examined the genetic architecture of TS and OCD in a variety of ways. We found that rare genetic changes account for more genetic risk in TS than in OCD; certain chromosomes contribute to OCD risk more than others; and variants that influence the level of genes expressed in two regions of the brain can account for a significant amount of risk for both TS and OCD. Results from this study might help in determining where, and what kind of variants are individual risk factors for TS and OCD and where they might be located in the human genome. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pgen.1003864 DP - University of Cape Town J1 - PLOS Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture TI - Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture UR - http://hdl.handle.net/11427/16075 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16075
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pgen.1003864
dc.identifier.vancouvercitationDavis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, et al. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLOS Genetics. 2013; http://hdl.handle.net/11427/16075.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Davis et al.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLOS Geneticsen_ZA
dc.source.urihttp://journals.plos.org/plosgeneticsen_ZA
dc.subject.otherTourette syndromeen_ZA
dc.subject.otherGenome-wide association studiesen_ZA
dc.subject.otherChromosomesen_ZA
dc.subject.otherCerebellumen_ZA
dc.subject.otherParietal lobeen_ZA
dc.subject.otherVariant genotypesen_ZA
dc.subject.otherObsessive-compulsive disorderen_ZA
dc.subject.otherChromosome 15en_ZA
dc.titlePartitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architectureen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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