Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape

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dc.contributor.advisorNaidoo, Richarden_ZA
dc.contributor.authorJaca, Anelisaen_ZA
dc.date.accessioned2014-07-28T14:57:27Z
dc.date.available2014-07-28T14:57:27Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractGastric cancer is commonly seen in the Western Cape. There are numerous factors that contribute to the development of this cancer and these include both environmental and genetic factors. Amongst the genetic factors, the E-cadherin (CDH1) gene is said to play a major role in the development of gastric cancer. Both germline and somatic mutations have been identified in the CDH1 gene. The germline mutations span the entire exon of this gene and are seen in approximately 29% to 56% of familial gastric cancers. On the other hand, CDH1 somatic mutations are seen in approximately 31% of sporadic cancers. These mutations have been identified in exons 7 to 10, with exons 8 and 9 being the commonly mutated regions. The primary objective of this study was to determine the prevalence of CDH1 genetic mutations in gastric cancer in the Western Cape and to correlate these findings with the demographic/clinicopathologic data.en_ZA
dc.identifier.apacitationJaca, A. (2013). <i>Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/3165en_ZA
dc.identifier.chicagocitationJaca, Anelisa. <i>"Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2013. http://hdl.handle.net/11427/3165en_ZA
dc.identifier.citationJaca, A. 2013. Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jaca, Anelisa AB - Gastric cancer is commonly seen in the Western Cape. There are numerous factors that contribute to the development of this cancer and these include both environmental and genetic factors. Amongst the genetic factors, the E-cadherin (CDH1) gene is said to play a major role in the development of gastric cancer. Both germline and somatic mutations have been identified in the CDH1 gene. The germline mutations span the entire exon of this gene and are seen in approximately 29% to 56% of familial gastric cancers. On the other hand, CDH1 somatic mutations are seen in approximately 31% of sporadic cancers. These mutations have been identified in exons 7 to 10, with exons 8 and 9 being the commonly mutated regions. The primary objective of this study was to determine the prevalence of CDH1 genetic mutations in gastric cancer in the Western Cape and to correlate these findings with the demographic/clinicopathologic data. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape TI - Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape UR - http://hdl.handle.net/11427/3165 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3165
dc.identifier.vancouvercitationJaca A. Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3165en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleSequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Capeen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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