Haemozoin formation
| dc.contributor.author | Egan, Timothy J | |
| dc.date.accessioned | 2016-07-15T14:33:53Z | |
| dc.date.available | 2016-07-15T14:33:53Z | |
| dc.date.issued | 2008 | |
| dc.date.updated | 2016-07-15T14:31:39Z | |
| dc.description.abstract | Formation of malaria pigment or haemozoin is the major route of haem detoxification in the malaria parasite Plasmodium falciparum as well as several other species of haematophagous organisms, including other Plasmodium species, helminth worms such as Schistosoma mansoni and blood-sucking insects such as Rhodnius prolixus. Recent advances in our understanding of the formation of haemozoin, both from new observations that it is formed within lipid bodies in P. falciparum and S. mansoni and biomimetic studies on the formation of its synthetic counterpart -haematin are reviewed. The review also covers methods available for screening compounds for their ability to inhibit -haematin formation. | en_ZA |
| dc.identifier | http://dx.doi.org/10.1016/j.molbiopara.2007.11.005 | |
| dc.identifier.apacitation | Egan, T. J. (2008). Haemozoin formation. <i>Molecular and Biochemical Parasitology</i>, http://hdl.handle.net/11427/20392 | en_ZA |
| dc.identifier.chicagocitation | Egan, Timothy J "Haemozoin formation." <i>Molecular and Biochemical Parasitology</i> (2008) http://hdl.handle.net/11427/20392 | en_ZA |
| dc.identifier.citation | Egan, T. J. (2008). Haemozoin formation. Molecular and biochemical parasitology, 157(2), 127-136. | en_ZA |
| dc.identifier.issn | 0166-685 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Egan, Timothy J AB - Formation of malaria pigment or haemozoin is the major route of haem detoxification in the malaria parasite Plasmodium falciparum as well as several other species of haematophagous organisms, including other Plasmodium species, helminth worms such as Schistosoma mansoni and blood-sucking insects such as Rhodnius prolixus. Recent advances in our understanding of the formation of haemozoin, both from new observations that it is formed within lipid bodies in P. falciparum and S. mansoni and biomimetic studies on the formation of its synthetic counterpart -haematin are reviewed. The review also covers methods available for screening compounds for their ability to inhibit -haematin formation. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - Molecular and Biochemical Parasitology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 SM - 0166-685 T1 - Haemozoin formation TI - Haemozoin formation UR - http://hdl.handle.net/11427/20392 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/20392 | |
| dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S016668510700312X | |
| dc.identifier.vancouvercitation | Egan TJ. Haemozoin formation. Molecular and Biochemical Parasitology. 2008; http://hdl.handle.net/11427/20392. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | Elsevier | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | Molecular and Biochemical Parasitology | en_ZA |
| dc.source.uri | http://www.journals.elsevier.com/molecular-and-biochemical-parasitology/ | |
| dc.subject.other | Haemozoin | |
| dc.subject.other | -Haematin | |
| dc.subject.other | Malaria | |
| dc.subject.other | Schistosoma mansoni | |
| dc.subject.other | Screening | |
| dc.subject.other | Lipid bodies | |
| dc.title | Haemozoin formation | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |