Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study

Simple item page
dc.contributor.authorKaze, Francoisen_ZA
dc.contributor.authorNjukeng, Francisen_ZA
dc.contributor.authorKengne, Andre-Pascalen_ZA
dc.contributor.authorAshuntantang, Gloriaen_ZA
dc.contributor.authorMbu, Robinsonen_ZA
dc.contributor.authorHalle, Marieen_ZA
dc.contributor.authorAsonganyi, Tazoachaen_ZA
dc.date.accessioned2015-11-27T09:33:41Z
dc.date.available2015-11-27T09:33:41Z
dc.date.issued2014en_ZA
dc.description.abstractBACKGROUND: Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. METHODS: This was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaounde Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria. RESULTS: During follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p<0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6weeks, 3months and 6months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months. CONCLUSION: Hypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications.en_ZA
dc.identifier.apacitationKaze, F., Njukeng, F., Kengne, A., Ashuntantang, G., Mbu, R., Halle, M., & Asonganyi, T. (2014). Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study. <i>BMC Pregnancy and Childbirth</i>, http://hdl.handle.net/11427/15400en_ZA
dc.identifier.chicagocitationKaze, Francois, Francis Njukeng, Andre-Pascal Kengne, Gloria Ashuntantang, Robinson Mbu, Marie Halle, and Tazoacha Asonganyi "Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study." <i>BMC Pregnancy and Childbirth</i> (2014) http://hdl.handle.net/11427/15400en_ZA
dc.identifier.citationKaze, F. F., Njukeng, F. A., Kengne, A. P., Ashuntantang, G., Mbu, R., Halle, M. P., & Asonganyi, T. (2014). Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study. BMC pregnancy and childbirth, 14(1), 134.en_ZA
dc.identifier.ris TY - Journal Article AU - Kaze, Francois AU - Njukeng, Francis AU - Kengne, Andre-Pascal AU - Ashuntantang, Gloria AU - Mbu, Robinson AU - Halle, Marie AU - Asonganyi, Tazoacha AB - BACKGROUND: Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. METHODS: This was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaounde Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria. RESULTS: During follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p<0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6weeks, 3months and 6months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months. CONCLUSION: Hypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications. DA - 2014 DB - OpenUCT DO - 10.1186/1471-2393-14-134 DP - University of Cape Town J1 - BMC Pregnancy and Childbirth LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study TI - Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study UR - http://hdl.handle.net/11427/15400 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15400
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2393-14-134
dc.identifier.vancouvercitationKaze F, Njukeng F, Kengne A, Ashuntantang G, Mbu R, Halle M, et al. Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study. BMC Pregnancy and Childbirth. 2014; http://hdl.handle.net/11427/15400.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2014 Kaze et al.; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Pregnancy and Childbirthen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcpregnancychildbirth/en_ZA
dc.subject.otherPreeclampsiaen_ZA
dc.subject.otherEclampsiaen_ZA
dc.subject.otherHypertensionen_ZA
dc.subject.otherProteinuriaen_ZA
dc.titlePost-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kaze_Post_partum_trend_a_2014.pdf
Size:
730.59 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles