How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

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dc.contributor.authorGuantai, Ericen_ZA
dc.contributor.authorChibale, Kellyen_ZA
dc.date.accessioned2015-10-28T07:10:31Z
dc.date.available2015-10-28T07:10:31Z
dc.date.issued2011en_ZA
dc.description.abstractMalaria continues to be an enormous global health challenge, with millions of new infections and deaths reported annually. This is partly due to the development of resistance by the malaria parasite to the majority of established anti-malarial drugs, a situation that continues to hamper attempts at controlling the disease. This has spurred intensive drug discovery endeavours geared towards identifying novel, highly active anti-malarial drugs, and the identification of quality leads from natural sources would greatly augment these efforts. The current reality is that other than compounds that have their foundation in historic natural products, there are no other compounds in drug discovery as part of lead optimization projects and preclinical development or further that have originated from a natural product start-point in recent years. This paper briefly presents both classical as well as some more modern, but underutilized, approaches that have been applied outside the field of malaria, and which could be considered in enhancing the potential of natural products to provide or inspire the development of anti-malarial lead compounds.en_ZA
dc.identifier.apacitationGuantai, E., & Chibale, K. (2011). How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?. <i>Malaria Journal</i>, http://hdl.handle.net/11427/14490en_ZA
dc.identifier.chicagocitationGuantai, Eric, and Kelly Chibale "How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?." <i>Malaria Journal</i> (2011) http://hdl.handle.net/11427/14490en_ZA
dc.identifier.citationGuantai, E., & Chibale, K. (2011). How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials. Malar J, 10(Suppl 1), S2.en_ZA
dc.identifier.ris TY - Journal Article AU - Guantai, Eric AU - Chibale, Kelly AB - Malaria continues to be an enormous global health challenge, with millions of new infections and deaths reported annually. This is partly due to the development of resistance by the malaria parasite to the majority of established anti-malarial drugs, a situation that continues to hamper attempts at controlling the disease. This has spurred intensive drug discovery endeavours geared towards identifying novel, highly active anti-malarial drugs, and the identification of quality leads from natural sources would greatly augment these efforts. The current reality is that other than compounds that have their foundation in historic natural products, there are no other compounds in drug discovery as part of lead optimization projects and preclinical development or further that have originated from a natural product start-point in recent years. This paper briefly presents both classical as well as some more modern, but underutilized, approaches that have been applied outside the field of malaria, and which could be considered in enhancing the potential of natural products to provide or inspire the development of anti-malarial lead compounds. DA - 2011 DB - OpenUCT DO - 10.1186/1475-2875-10-S1-S2 DP - University of Cape Town J1 - Malaria Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? TI - How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? UR - http://hdl.handle.net/11427/14490 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14490
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2875-10-S1-S2
dc.identifier.vancouvercitationGuantai E, Chibale K. How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?. Malaria Journal. 2011; http://hdl.handle.net/11427/14490.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Guantai and Chibale; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceMalaria Journalen_ZA
dc.source.urihttp://www.malariajournal.com/en_ZA
dc.subject.otherAntimalarialsen_ZA
dc.subject.otherBiological Productsen_ZA
dc.subject.otherDrug Therapy, Combinationen_ZA
dc.subject.otherMalariaen_ZA
dc.titleHow can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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