Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes

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dc.contributor.authorAshkani, Jahanshah
dc.contributor.authorNaidoo, Kevin J
dc.date.accessioned2021-10-08T07:16:02Z
dc.date.available2021-10-08T07:16:02Z
dc.date.issued2016
dc.description.abstractAberrant glycosylation in tumours stem from altered glycosyltransferase (GT) gene expression but can the expression profiles of these signature genes be used to classify cancer types and lead to cancer subtype discovery? The differential structural changes to cellular glycan structures are predominantly regulated by the expression patterns of GT genes and are a hallmark of neoplastic cell metamorphoses. We found that the expression of 210 GT genes taken from 1893 cancer patient samples in The Cancer Genome Atlas (TCGA) microarray data are able to classify six cancers; breast, ovarian, glioblastoma, kidney, colon and lung. The GT gene expression profiles are used to develop cancer classifiers and propose subtypes. The subclassification of breast cancer solid tumour samples illustrates the discovery of subgroups from GT genes that match well against basal-like and HER2-enriched subtypes and correlates to clinical, mutation and survival data. This cancer type glycosyltransferase gene signature finding provides foundational evidence for the centrality of glycosylation in cancer.
dc.identifier.apacitationAshkani, J., & Naidoo, K. J. (2016). Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes. <i>Scientific Reports</i>, 6(1), 174 - 177. http://hdl.handle.net/11427/34754en_ZA
dc.identifier.chicagocitationAshkani, Jahanshah, and Kevin J Naidoo "Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes." <i>Scientific Reports</i> 6, 1. (2016): 174 - 177. http://hdl.handle.net/11427/34754en_ZA
dc.identifier.citationAshkani, J. & Naidoo, K.J. 2016. Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes. <i>Scientific Reports.</i> 6(1):174 - 177. http://hdl.handle.net/11427/34754en_ZA
dc.identifier.issn2045-2322
dc.identifier.ris TY - Journal Article AU - Ashkani, Jahanshah AU - Naidoo, Kevin J AB - Aberrant glycosylation in tumours stem from altered glycosyltransferase (GT) gene expression but can the expression profiles of these signature genes be used to classify cancer types and lead to cancer subtype discovery? The differential structural changes to cellular glycan structures are predominantly regulated by the expression patterns of GT genes and are a hallmark of neoplastic cell metamorphoses. We found that the expression of 210 GT genes taken from 1893 cancer patient samples in The Cancer Genome Atlas (TCGA) microarray data are able to classify six cancers; breast, ovarian, glioblastoma, kidney, colon and lung. The GT gene expression profiles are used to develop cancer classifiers and propose subtypes. The subclassification of breast cancer solid tumour samples illustrates the discovery of subgroups from GT genes that match well against basal-like and HER2-enriched subtypes and correlates to clinical, mutation and survival data. This cancer type glycosyltransferase gene signature finding provides foundational evidence for the centrality of glycosylation in cancer. DA - 2016 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Scientific Reports LK - https://open.uct.ac.za PY - 2016 SM - 2045-2322 T1 - Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes TI - Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes UR - http://hdl.handle.net/11427/34754 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34754
dc.identifier.vancouvercitationAshkani J, Naidoo KJ. Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes. Scientific Reports. 2016;6(1):174 - 177. http://hdl.handle.net/11427/34754.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Chemistry
dc.publisher.facultyFaculty of Science
dc.sourceScientific Reports
dc.source.journalissue1
dc.source.journalvolume6
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1038/srep26451
dc.subject.otherDatabases, Genetic
dc.subject.otherFemale
dc.subject.otherGene Expression Profiling
dc.subject.otherGene Expression Regulation, Neoplastic
dc.subject.otherGlycosyltransferases
dc.subject.otherHumans
dc.subject.otherMale
dc.subject.otherMutation
dc.subject.otherNeoplasms
dc.subject.otherOligonucleotide Array Sequence Analysis
dc.subject.otherPrincipal Component Analysis
dc.subject.otherPrognosis
dc.subject.otherSurvival Analysis
dc.subject.otherGlycosyltransferases
dc.titleGlycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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