The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy

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dc.contributor.advisorMyer, Landonen_ZA
dc.contributor.authorBanga, Agatha Tafadzwaen_ZA
dc.date.accessioned2018-02-09T12:48:11Z
dc.date.available2018-02-09T12:48:11Z
dc.date.issued2017en_ZA
dc.description.abstractObjective: To investigate hearing loss among perinatally HIV-infected (PHIV+) adolescents on antiretroviral therapy (ART), and HIV-non-infected (HIV-) adolescents in Cape Town, South Africa. Methods: A cross-sectional analysis was carried out to describe the prevalence, nature and predictors (demographic, past medical history, clinical findings) of hearing loss in adolescents between 9 and 14 years of age. Screening pure-tone air-conduction (AC) thresholds above 30 decibels (dB) were considered to be indicative of debilitating hearing loss. Statistical analysis included univariate analysis and multivariate logistic regression. Results: The cross-sectional analysis included data from 540 participants; consisting 273 males (51%), 267 females, 432 PHIV+ and 108 HIV-, with a median age of 12 years. Hearing impairment was observed in 19% of all the adolescents in the study. Multivariate analysis showed the following predictors for any hearing loss: an unmarried primary caregiver (odds ratio (OR) 0.59; 95% confidence interval (CI), 0.39;0.91, p = 0.015), being female (OR 1.67; 95% CI, 1.12;2.51; p = 0.013) and reports of being troubled by ear pain or discharge in the last month (OR 2.54; 95% CI, 1.55;4.17; p = <0.001) after adjustment. Univariate analysis showed an association between hearing loss and a longer duration on ART among PHIV+ adolescents (OR 1.80, 95%CI 1.17;2.75, p = 0.007). Conclusion: The prevalence of hearing loss appears to be comparable between PHIV+ and HIVadolescents in Cape Town. In low resource settings, a history of ear pain or discharge within the last month may be used as a screening tool for a hearing assessment, and guide referral for formal hearing tests.en_ZA
dc.identifier.apacitationBanga, A. T. (2017). <i>The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Centre for Infectious Disease Epidemiology and Research (CIDER). Retrieved from http://hdl.handle.net/11427/27473en_ZA
dc.identifier.chicagocitationBanga, Agatha Tafadzwa. <i>"The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Centre for Infectious Disease Epidemiology and Research (CIDER), 2017. http://hdl.handle.net/11427/27473en_ZA
dc.identifier.citationBanga, A. 2017. The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Banga, Agatha Tafadzwa AB - Objective: To investigate hearing loss among perinatally HIV-infected (PHIV+) adolescents on antiretroviral therapy (ART), and HIV-non-infected (HIV-) adolescents in Cape Town, South Africa. Methods: A cross-sectional analysis was carried out to describe the prevalence, nature and predictors (demographic, past medical history, clinical findings) of hearing loss in adolescents between 9 and 14 years of age. Screening pure-tone air-conduction (AC) thresholds above 30 decibels (dB) were considered to be indicative of debilitating hearing loss. Statistical analysis included univariate analysis and multivariate logistic regression. Results: The cross-sectional analysis included data from 540 participants; consisting 273 males (51%), 267 females, 432 PHIV+ and 108 HIV-, with a median age of 12 years. Hearing impairment was observed in 19% of all the adolescents in the study. Multivariate analysis showed the following predictors for any hearing loss: an unmarried primary caregiver (odds ratio (OR) 0.59; 95% confidence interval (CI), 0.39;0.91, p = 0.015), being female (OR 1.67; 95% CI, 1.12;2.51; p = 0.013) and reports of being troubled by ear pain or discharge in the last month (OR 2.54; 95% CI, 1.55;4.17; p = <0.001) after adjustment. Univariate analysis showed an association between hearing loss and a longer duration on ART among PHIV+ adolescents (OR 1.80, 95%CI 1.17;2.75, p = 0.007). Conclusion: The prevalence of hearing loss appears to be comparable between PHIV+ and HIVadolescents in Cape Town. In low resource settings, a history of ear pain or discharge within the last month may be used as a screening tool for a hearing assessment, and guide referral for formal hearing tests. DA - 2017 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy TI - The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy UR - http://hdl.handle.net/11427/27473 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27473
dc.identifier.vancouvercitationBanga AT. The prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Centre for Infectious Disease Epidemiology and Research (CIDER), 2017 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27473en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentCentre for Infectious Disease Epidemiology and Research (CIDER)en_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherEpidemiologyen_ZA
dc.subject.otherHearing Lossen_ZA
dc.subject.otherantiretroviral therapyen_ZA
dc.titleThe prevalence of hearing loss in HIV-infected South African adolescents on antiretroviral therapyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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