The crossed mesostriatal pathway and circling behaviour in rats

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dc.contributor.advisorDouglas, Rodney Jen_ZA
dc.contributor.authorVan Wageningen, Gerhard Dereken_ZA
dc.date.accessioned2016-08-05T10:54:29Z
dc.date.available2016-08-05T10:54:29Z
dc.date.issued1987en_ZA
dc.descriptionBibliography: pages 326-345.en_ZA
dc.description.abstractRats with unilateral 6-OHDA lesions of the nigrostriatal (NS) projection display motor asymmetry in the form of rotational behaviour. The rotation is in the direction ipsilateral with respect to the lesioned side (Ungerstedt 1979). The nett ipsilateral rotations decrease with time, from 1 week to about a month. This decrease has been interpreted as recovery from the lesion-induced motor asymmetry (Glick and Cox 1978). Pritzel et al. (1983) have ascribed the recovery from motor asymmetry to increased activity of a crossed NS projection, which is spared by the ipsilateral lesion. The present study has defined the size and anatomical path of this crossed projection, and has examined its involvement in the behavioural recovery of rats from lesion-induced motor asymmetry. The anatomy of the crossed projection was investigated in male Long-Evans rats using retrograde HRP tract tracing from deposition sites in the striatum.en_ZA
dc.identifier.apacitationVan Wageningen, G. D. (1987). <i>The crossed mesostriatal pathway and circling behaviour in rats</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/21152en_ZA
dc.identifier.chicagocitationVan Wageningen, Gerhard Derek. <i>"The crossed mesostriatal pathway and circling behaviour in rats."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 1987. http://hdl.handle.net/11427/21152en_ZA
dc.identifier.citationVan Wageningen, G. 1987. The crossed mesostriatal pathway and circling behaviour in rats. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van Wageningen, Gerhard Derek AB - Rats with unilateral 6-OHDA lesions of the nigrostriatal (NS) projection display motor asymmetry in the form of rotational behaviour. The rotation is in the direction ipsilateral with respect to the lesioned side (Ungerstedt 1979). The nett ipsilateral rotations decrease with time, from 1 week to about a month. This decrease has been interpreted as recovery from the lesion-induced motor asymmetry (Glick and Cox 1978). Pritzel et al. (1983) have ascribed the recovery from motor asymmetry to increased activity of a crossed NS projection, which is spared by the ipsilateral lesion. The present study has defined the size and anatomical path of this crossed projection, and has examined its involvement in the behavioural recovery of rats from lesion-induced motor asymmetry. The anatomy of the crossed projection was investigated in male Long-Evans rats using retrograde HRP tract tracing from deposition sites in the striatum. DA - 1987 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1987 T1 - The crossed mesostriatal pathway and circling behaviour in rats TI - The crossed mesostriatal pathway and circling behaviour in rats UR - http://hdl.handle.net/11427/21152 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/21152
dc.identifier.vancouvercitationVan Wageningen GD. The crossed mesostriatal pathway and circling behaviour in rats. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 1987 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/21152en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPhysiologyen_ZA
dc.titleThe crossed mesostriatal pathway and circling behaviour in ratsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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