Dyslipidaemia

Journal Article

2003

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South African Journal for Continuing Medical Education

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University of Cape Town

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Abstract
Modern clinical practice commonly deals with the complications of atherosclerosis both in acute and potentially life-threatening and severely debilitating manifestations, and in chronic manifestations that may result in marked impairment of exercise and working capacity. Epidemiological information and intervention with drugs clearly indicate that atherosclerosis can be limited. Plasma lipids have been implicated in the pathogenesis of atherosclerosis, with variable strength of association: severe metabolic errors increasing risk profoundly while ‘moderate’ hypercholesterolaemia and low concentrations of high-density lipoprotein in concert with other risk factors can also signify a high risk. Other clinical problems linked with errors in lipid and lipoprotein metabolism include pancreatitis, malabsorption and many other rarer syndromes.
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