The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Simple item page
dc.contributor.authorLee, Sueen_ZA
dc.contributor.authorStepniewska, Kasiaen_ZA
dc.contributor.authorAnstey, Nicholasen_ZA
dc.contributor.authorAshley, Elizabethen_ZA
dc.contributor.authorBarnes, Karenen_ZA
dc.contributor.authorBinh, Tranen_ZA
dc.contributor.authorD'Alessandro, Umbertoen_ZA
dc.contributor.authorDay, Nicholasen_ZA
dc.contributor.authorde Vries, Peteren_ZA
dc.contributor.authorDorsey, Granten_ZA
dc.contributor.authorGuthmann, Jean-Paulen_ZA
dc.contributor.authorMayxay, Mayfongen_ZA
dc.contributor.authorNewton, Paulen_ZA
dc.contributor.authorNosten, Francoisen_ZA
dc.contributor.authorOlliaro, Pieroen_ZA
dc.date.accessioned2015-10-28T07:07:12Z
dc.date.available2015-10-28T07:07:12Z
dc.date.issued2008en_ZA
dc.description.abstractBACKGROUND:Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS: Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. RESULTS: A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/- SD) of -0.69 (+/- 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). CONCLUSION: Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.en_ZA
dc.identifier.apacitationLee, S., Stepniewska, K., Anstey, N., Ashley, E., Barnes, K., Binh, T., ... Olliaro, P. (2008). The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. <i>Malaria Journal</i>, http://hdl.handle.net/11427/14473en_ZA
dc.identifier.chicagocitationLee, Sue, Kasia Stepniewska, Nicholas Anstey, Elizabeth Ashley, Karen Barnes, Tran Binh, Umberto D'Alessandro, et al "The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria." <i>Malaria Journal</i> (2008) http://hdl.handle.net/11427/14473en_ZA
dc.identifier.citationLee, S. J., Stepniewska, K., Anstey, N., Ashley, E., Barnes, K., Binh, T. Q., ... & White, N. J. (2008). The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. Malaria journal, 7(1), 149.en_ZA
dc.identifier.ris TY - Journal Article AU - Lee, Sue AU - Stepniewska, Kasia AU - Anstey, Nicholas AU - Ashley, Elizabeth AU - Barnes, Karen AU - Binh, Tran AU - D'Alessandro, Umberto AU - Day, Nicholas AU - de Vries, Peter AU - Dorsey, Grant AU - Guthmann, Jean-Paul AU - Mayxay, Mayfong AU - Newton, Paul AU - Nosten, Francois AU - Olliaro, Piero AB - BACKGROUND:Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS: Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. RESULTS: A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/- SD) of -0.69 (+/- 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). CONCLUSION: Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. DA - 2008 DB - OpenUCT DO - 10.1186/1475-2875-7-149 DP - University of Cape Town J1 - Malaria Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria TI - The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria UR - http://hdl.handle.net/11427/14473 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14473
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2875-7-149
dc.identifier.vancouvercitationLee S, Stepniewska K, Anstey N, Ashley E, Barnes K, Binh T, et al. The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. Malaria Journal. 2008; http://hdl.handle.net/11427/14473.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2008 Lee et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceMalaria Journalen_ZA
dc.source.urihttp://www.malariajournal.com/en_ZA
dc.subject.otherMalariaen_ZA
dc.subject.otherClinical Pharmacologyen_ZA
dc.titleThe relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malariaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lee_Relationship_between_haemoglobin_concentration_2008.pdf
Size:
408.28 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles