Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus

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dc.contributor.advisorSwingler, George Hen_ZA
dc.contributor.advisorZar, Heatheren_ZA
dc.contributor.authorFatti, Geoffrey Liberoen_ZA
dc.date.accessioned2014-11-08T08:06:34Z
dc.date.available2014-11-08T08:06:34Z
dc.date.issued2005en_ZA
dc.descriptionIncludes bibliographical references (leaves 53-60).en_ZA
dc.description.abstractPneumocystis pneumonia (PCP) is an important cause of morbidity and mortality amongst HIV-infected children in Africa. Definitive diagnostic resources for PCP in Africa are limited due to their expense and technical difficulty, however recognising and treating children at risk is essential. As management decisions for children with pneumonia are made primarily on a clinical basis in many African regions, it is important to attempt to define a valid clinical diagnostic technique for PCP that could be used by clinicians to determine the use of correct empirical antibiotic therapy. The objectives of this study were to identify clinical features (associated with PCP in HIV-infected children hospitalised with pneumonia, to determine the combination of features that best predicts PCP in these children, and to calculate the diagnostic accuracy of these features. This study was a re-analysis of a database of a prospective study. Consecutive children below ten years of age, with a primary diagnosis of pneumonia or severe pneumonia, and who were known to be HIV-infected or were suspected of having HIV infection, were included prospectively over a 12 month period. Clinical data and diagnostic testing for PCP were obtained on admission. Bi­ and multivariate analysis of associations of the clinical variables with PCP were performed using logistic regression, to identify the combination of variables that best predicted PCP. The diagnostic accuracy of the best predicted features were calculated.en_ZA
dc.identifier.apacitationFatti, G. L. (2005). <i>Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/9376en_ZA
dc.identifier.chicagocitationFatti, Geoffrey Libero. <i>"Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2005. http://hdl.handle.net/11427/9376en_ZA
dc.identifier.citationFatti, G. 2005. Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Fatti, Geoffrey Libero AB - Pneumocystis pneumonia (PCP) is an important cause of morbidity and mortality amongst HIV-infected children in Africa. Definitive diagnostic resources for PCP in Africa are limited due to their expense and technical difficulty, however recognising and treating children at risk is essential. As management decisions for children with pneumonia are made primarily on a clinical basis in many African regions, it is important to attempt to define a valid clinical diagnostic technique for PCP that could be used by clinicians to determine the use of correct empirical antibiotic therapy. The objectives of this study were to identify clinical features (associated with PCP in HIV-infected children hospitalised with pneumonia, to determine the combination of features that best predicts PCP in these children, and to calculate the diagnostic accuracy of these features. This study was a re-analysis of a database of a prospective study. Consecutive children below ten years of age, with a primary diagnosis of pneumonia or severe pneumonia, and who were known to be HIV-infected or were suspected of having HIV infection, were included prospectively over a 12 month period. Clinical data and diagnostic testing for PCP were obtained on admission. Bi­ and multivariate analysis of associations of the clinical variables with PCP were performed using logistic regression, to identify the combination of variables that best predicted PCP. The diagnostic accuracy of the best predicted features were calculated. DA - 2005 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus TI - Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus UR - http://hdl.handle.net/11427/9376 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9376
dc.identifier.vancouvercitationFatti GL. Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2005 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9376en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Healthen_ZA
dc.titleClinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virusen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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