The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review

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dc.contributor.advisorEngel, Mark Een_ZA
dc.contributor.advisorAbdullahi, Leila Hen_ZA
dc.contributor.authorMoloi, Annesinahen_ZA
dc.date.accessioned2016-01-29T11:02:11Z
dc.date.available2016-01-29T11:02:11Z
dc.date.issued2015en_ZA
dc.descriptionIncludes bibliographical referencesen_ZA
dc.description.abstractAsymptomatic children can be a major reservoir of pharyngeal Group A Streptococcus (GAS) with reported figures ranging from <10% to >20% in developing countries. There is a need to document GAS carriage in school children, which, together with the molecular characterisation (M-typing) of strains harboured in the pharynx of carriers, will help to ascertain the extent to which disease strains are prevalent amongst carriers. This background information would serve to assist healthcare providers in diagnosing symptomatic GAS pharyngitis, as well as could potentially contribute to the development of a GAS vaccine. Currently, data on GAS carriage prevalence and M-type distribution in African countries are largely scant. We therefore undertook to perform a systematic review to determine the prevalence and type distribution of asymptomatic streptococcus carriage in children aged 5 -15years, residing in African countries. Methods: We conducted a comprehensive literature search among a number of databases, using an African search filter to identify GAS prevalence studies that report on children between the ages of 5 - 15 years who reside in African countries. Electronic searches were complemented by a hand search performed on reference lists of potentially included studies. The search was not limited by year of publication and language. Two evaluators independently reviewed, rated, and abstracted data from each article. Prevalence estimates were pooled in a meta-analysis and stratified according to region and study design using Stata®. Specifically, we applied the random effects metaprop routine to aggregate prevalence estimates and account for between study variability in calculating the overall pooled estimates and 95% CI for GAS carriage prevalence.en_ZA
dc.identifier.apacitationMoloi, A. (2015). <i>The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/16604en_ZA
dc.identifier.chicagocitationMoloi, Annesinah. <i>"The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2015. http://hdl.handle.net/11427/16604en_ZA
dc.identifier.citationMoloi, A. 2015. The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Moloi, Annesinah AB - Asymptomatic children can be a major reservoir of pharyngeal Group A Streptococcus (GAS) with reported figures ranging from <10% to >20% in developing countries. There is a need to document GAS carriage in school children, which, together with the molecular characterisation (M-typing) of strains harboured in the pharynx of carriers, will help to ascertain the extent to which disease strains are prevalent amongst carriers. This background information would serve to assist healthcare providers in diagnosing symptomatic GAS pharyngitis, as well as could potentially contribute to the development of a GAS vaccine. Currently, data on GAS carriage prevalence and M-type distribution in African countries are largely scant. We therefore undertook to perform a systematic review to determine the prevalence and type distribution of asymptomatic streptococcus carriage in children aged 5 -15years, residing in African countries. Methods: We conducted a comprehensive literature search among a number of databases, using an African search filter to identify GAS prevalence studies that report on children between the ages of 5 - 15 years who reside in African countries. Electronic searches were complemented by a hand search performed on reference lists of potentially included studies. The search was not limited by year of publication and language. Two evaluators independently reviewed, rated, and abstracted data from each article. Prevalence estimates were pooled in a meta-analysis and stratified according to region and study design using Stata®. Specifically, we applied the random effects metaprop routine to aggregate prevalence estimates and account for between study variability in calculating the overall pooled estimates and 95% CI for GAS carriage prevalence. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review TI - The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review UR - http://hdl.handle.net/11427/16604 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16604
dc.identifier.vancouvercitationMoloi A. The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/16604en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Healthen_ZA
dc.subject.otherStreptococcusen_ZA
dc.subject.otherGroup A Streptococcusen_ZA
dc.subject.otherCarriageen_ZA
dc.subject.otherCarrier stateen_ZA
dc.subject.otheren_ZA
dc.titleThe prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic reviewen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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