The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa

dc.contributor.authorAtaher, Quazien_ZA
dc.contributor.authorPortsmouth, Simonen_ZA
dc.contributor.authorNapolitano, Lauraen_ZA
dc.contributor.authorEng, Sybilen_ZA
dc.contributor.authorGreenacre, Annaen_ZA
dc.contributor.authorKambugu, Andrewen_ZA
dc.contributor.authorWood, Robinen_ZA
dc.contributor.authorBadal-Faesen, Sharlaaen_ZA
dc.contributor.authorTressler, Randyen_ZA
dc.date.accessioned2015-11-18T03:54:14Z
dc.date.available2015-11-18T03:54:14Z
dc.date.issued2012en_ZA
dc.description.abstractBACKGROUND: The introduction of C-C chemokine receptor type-5 (CCR5) antagonists as antiretroviral therapy has led to the need to study HIV co-receptor tropism in different HIV-1 subtypes and geographical locations. This study was undertaken to evaluate HIV-1 co-receptor tropism in the developing world where non-B subtypes predominate, in order to assess the therapeutic and prophylactic potential of CCR5 antagonists in these regions. METHODS: HIV-1-infected patients were recruited into this prospective, cross-sectional, epidemiologic study from HIV clinics in South Africa, Uganda and India. Patients were infected with subtypes C (South Africa, India) or A or D (Uganda). HIV-1 subtype and co-receptor tropism were determined and analyzed with disease characteristics, including viral load and CD4+ and CD8+ T cell counts. RESULTS: CCR5-tropic (R5) HIV-1 was detected in 96% of treatment-naive (TN) and treatment-experienced (TE) patients in India, 71% of TE South African patients, and 86% (subtype A/A1) and 71% (subtype D) of TN and TE Ugandan patients. Dual/mixed-tropic HIV-1 was found in 4% of Indian, 25% of South African and 13% (subtype A/A1) and 29% (subtype D) of Ugandan patients. Prior antiretroviral treatment was associated with decreased R5 tropism; however, this decrease was less in subtype C from India (TE: 94%, TN: 97%) than in subtypes A (TE: 59%; TN: 91%) and D (TE: 30%; TN: 79%). R5 virus infection in all three subtypes correlated with higher CD4+ count. CONCLUSIONS: R5 HIV-1 was predominant in TN individuals with HIV-1 subtypes C, A, and D and TE individuals with subtypes C and A. Higher CD4+ count correlated with R5 prevalence, while treatment experience was associated with increased non-R5 infection in all subtypes.en_ZA
dc.identifier.apacitationAtaher, Q., Portsmouth, S., Napolitano, L., Eng, S., Greenacre, A., Kambugu, A., ... Tressler, R. (2012). The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa. <i>Journal of the International AIDS Society</i>, http://hdl.handle.net/11427/15058en_ZA
dc.identifier.chicagocitationAtaher, Quazi, Simon Portsmouth, Laura Napolitano, Sybil Eng, Anna Greenacre, Andrew Kambugu, Robin Wood, Sharlaa Badal-Faesen, and Randy Tressler "The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa." <i>Journal of the International AIDS Society</i> (2012) http://hdl.handle.net/11427/15058en_ZA
dc.identifier.citationAtaher, Q., Portsmouth, S., Napolitano, L. A., Eng, S., Greenacre, A., Kambugu, A., ... & Tressler, R. (2012). The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa. Journal of the International AIDS Society, 15(1), 2.en_ZA
dc.identifier.ris TY - Journal Article AU - Ataher, Quazi AU - Portsmouth, Simon AU - Napolitano, Laura AU - Eng, Sybil AU - Greenacre, Anna AU - Kambugu, Andrew AU - Wood, Robin AU - Badal-Faesen, Sharlaa AU - Tressler, Randy AB - BACKGROUND: The introduction of C-C chemokine receptor type-5 (CCR5) antagonists as antiretroviral therapy has led to the need to study HIV co-receptor tropism in different HIV-1 subtypes and geographical locations. This study was undertaken to evaluate HIV-1 co-receptor tropism in the developing world where non-B subtypes predominate, in order to assess the therapeutic and prophylactic potential of CCR5 antagonists in these regions. METHODS: HIV-1-infected patients were recruited into this prospective, cross-sectional, epidemiologic study from HIV clinics in South Africa, Uganda and India. Patients were infected with subtypes C (South Africa, India) or A or D (Uganda). HIV-1 subtype and co-receptor tropism were determined and analyzed with disease characteristics, including viral load and CD4+ and CD8+ T cell counts. RESULTS: CCR5-tropic (R5) HIV-1 was detected in 96% of treatment-naive (TN) and treatment-experienced (TE) patients in India, 71% of TE South African patients, and 86% (subtype A/A1) and 71% (subtype D) of TN and TE Ugandan patients. Dual/mixed-tropic HIV-1 was found in 4% of Indian, 25% of South African and 13% (subtype A/A1) and 29% (subtype D) of Ugandan patients. Prior antiretroviral treatment was associated with decreased R5 tropism; however, this decrease was less in subtype C from India (TE: 94%, TN: 97%) than in subtypes A (TE: 59%; TN: 91%) and D (TE: 30%; TN: 79%). R5 virus infection in all three subtypes correlated with higher CD4+ count. CONCLUSIONS: R5 HIV-1 was predominant in TN individuals with HIV-1 subtypes C, A, and D and TE individuals with subtypes C and A. Higher CD4+ count correlated with R5 prevalence, while treatment experience was associated with increased non-R5 infection in all subtypes. DA - 2012 DB - OpenUCT DO - 10.1186/1758-2652-15-2 DP - University of Cape Town J1 - Journal of the International AIDS Society LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa TI - The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa UR - http://hdl.handle.net/11427/15058 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15058
dc.identifier.urihttp://dx.doi.org/10.1186/1758-2652-15-2
dc.identifier.vancouvercitationAtaher Q, Portsmouth S, Napolitano L, Eng S, Greenacre A, Kambugu A, et al. The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa. Journal of the International AIDS Society. 2012; http://hdl.handle.net/11427/15058.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Ataher et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceJournal of the International AIDS Societyen_ZA
dc.source.urihttp://archive.biomedcentral.com/1758-2652/en_ZA
dc.subject.otherC-C chemokine receptor type-5 (CCR5) antagonistsen_ZA
dc.subject.otherantiretroviral therapyen_ZA
dc.subject.otherHIV-1 subtypesen_ZA
dc.titleThe epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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