CANDLE SYNDROME: Orodfacial manifestations and dental implications

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dc.contributor.authorRoberts, T
dc.contributor.authorStephen, L
dc.contributor.authorScott, C
dc.contributor.authordi Pasquale, T
dc.contributor.authorNaser-eldin, A
dc.contributor.authorChetty, M
dc.contributor.authorShaik, S
dc.contributor.authorLewandowski, L
dc.contributor.authorBeighton, P
dc.date.accessioned2016-01-11T10:05:58Z
dc.date.available2016-01-11T10:05:58Z
dc.date.issued2015-12-28
dc.date.updated2015-12-28T19:03:45Z
dc.description.abstractA South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and osteopenia of her jaws, confirmed by digitalized radiography, were previously undescribed syndromic components. Intellectual impairment posed problems during dental intervention. The carious dental lesions and poor oral hygiene were treated conservatively under local anaesthetic. Prophylactic antibiotics were administered an hour before all procedures. Due to the nature of her general condition, invasive dental procedures were minimal. Regular follow-ups were scheduled at six monthly intervals. During this period, her overall oral health status had improved markedly. The CANDLE syndrome is a rare condition with grave complications including immunosuppression and diabetes mellitus. As with many genetic disorders, the dental manifestations are often overshadowed by other more conspicuous and complex syndromic features. Recognition of both the clinical and oral changes that occur in the CANDLE syndrome facilitates accurate diagnosis and appropriate dental management of this potentially lethal condition.en_ZA
dc.identifier.apacitationRoberts, T., Stephen, L., Scott, C., di Pasquale, T., Naser-eldin, A., Chetty, M., ... Beighton, P. (2015). CANDLE SYNDROME: Orodfacial manifestations and dental implications. <i>Head and Face Medicine</i>, http://hdl.handle.net/11427/16327en_ZA
dc.identifier.chicagocitationRoberts, T, L Stephen, C Scott, T di Pasquale, A Naser-eldin, M Chetty, S Shaik, L Lewandowski, and P Beighton "CANDLE SYNDROME: Orodfacial manifestations and dental implications." <i>Head and Face Medicine</i> (2015) http://hdl.handle.net/11427/16327en_ZA
dc.identifier.citationRoberts, T., et al. "CANDLE SYNDROME: Orodfacial manifestations and dental implications." Head & face medicine, 11(1):38en_ZA
dc.identifier.issn1746-160Xen_ZA
dc.identifier.ris TY - Journal Article AU - Roberts, T AU - Stephen, L AU - Scott, C AU - di Pasquale, T AU - Naser-eldin, A AU - Chetty, M AU - Shaik, S AU - Lewandowski, L AU - Beighton, P AB - A South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and osteopenia of her jaws, confirmed by digitalized radiography, were previously undescribed syndromic components. Intellectual impairment posed problems during dental intervention. The carious dental lesions and poor oral hygiene were treated conservatively under local anaesthetic. Prophylactic antibiotics were administered an hour before all procedures. Due to the nature of her general condition, invasive dental procedures were minimal. Regular follow-ups were scheduled at six monthly intervals. During this period, her overall oral health status had improved markedly. The CANDLE syndrome is a rare condition with grave complications including immunosuppression and diabetes mellitus. As with many genetic disorders, the dental manifestations are often overshadowed by other more conspicuous and complex syndromic features. Recognition of both the clinical and oral changes that occur in the CANDLE syndrome facilitates accurate diagnosis and appropriate dental management of this potentially lethal condition. DA - 2015-12-28 DB - OpenUCT DO - 10.1186/s13005-015-0095-4 DP - University of Cape Town J1 - Head and Face Medicine LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 SM - 1746-160X T1 - CANDLE SYNDROME: Orodfacial manifestations and dental implications TI - CANDLE SYNDROME: Orodfacial manifestations and dental implications UR - http://hdl.handle.net/11427/16327 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s13005-015-0095-4
dc.identifier.urihttp://hdl.handle.net/11427/16327
dc.identifier.vancouvercitationRoberts T, Stephen L, Scott C, di Pasquale T, Naser-eldin A, Chetty M, et al. CANDLE SYNDROME: Orodfacial manifestations and dental implications. Head and Face Medicine. 2015; http://hdl.handle.net/11427/16327.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentDivision of Rheumatologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderRoberts et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceHead and Face Medicineen_ZA
dc.source.urihttp://head-face-med.biomedcentral.com/
dc.titleCANDLE SYNDROME: Orodfacial manifestations and dental implicationsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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