Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy
| dc.contributor.author | Krige, J | |
| dc.contributor.author | Kotze, U | |
| dc.contributor.author | Shaw, J | |
| dc.contributor.author | Bornman, P | |
| dc.date.accessioned | 2016-11-10T09:56:25Z | |
| dc.date.available | 2016-11-10T09:56:25Z | |
| dc.date.issued | 2009 | |
| dc.date.updated | 2016-01-22T10:41:04Z | |
| dc.description.abstract | Background. This study evaluated the incidence of rebleeding and death at 6 weeks after a first episode of acute variceal haemorrhage (AVH) treated by emergency endoscopic sclerotherapy in a large cohort of alcoholic cirrhotic patients. Methods. From January 1984 to December 2006, 310 alcoholic cirrhotic patients (242 men, 68 women; mean age 51.7 years) with AVH underwent 786 endoscopic variceal injection treatments (342 emergency, 444 elective) during 919 endoscopy sessions in the first 6 weeks after the first variceal bleed. Endoscopic control of initial bleeding, variceal rebleeding and survival at 6 weeks were recorded. Results. Endoscopic intervention controlled AVH in 304 of 310 patients (98.1%). Seventy-five patients (24.2%) rebled, 38 (12.3%) within 5 days and 37 (11.9%) within 6 weeks. No patient scored as Child-Pugh A died. Seventy-seven (24.8%) Child-Pugh B and C patients died, 29 (9.3%) within 5 days and 48 (15.4%) between 6 and 42 days. Mortality increased exponentially as the Child-Pugh score increased, reaching 80% when the score exceeded 13. Conclusion. Despite initial control of variceal haemorrhage, 1 in 4 patients (24.2%) rebled within 6 weeks. Survival at 6 weeks was 75.2% and was influenced by the severity of liver failure, with most deaths occurring in Child-Pugh grade C patients. | |
| dc.identifier.apacitation | Krige, J., Kotze, U., Shaw, J., & Bornman, P. (2009). Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy. <i>South African Journal of Surgery</i>, http://hdl.handle.net/11427/22482 | en_ZA |
| dc.identifier.chicagocitation | Krige, J, U Kotze, J Shaw, and P Bornman "Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy." <i>South African Journal of Surgery</i> (2009) http://hdl.handle.net/11427/22482 | en_ZA |
| dc.identifier.citation | Krige, J., Kotze, U., Shaw, J., & Bornman, P. (2009). Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy. South African Journal of Surgery, 47(3). | |
| dc.identifier.issn | 2078-5151 | |
| dc.identifier.ris | TY - Journal Article AU - Krige, J AU - Kotze, U AU - Shaw, J AU - Bornman, P AB - Background. This study evaluated the incidence of rebleeding and death at 6 weeks after a first episode of acute variceal haemorrhage (AVH) treated by emergency endoscopic sclerotherapy in a large cohort of alcoholic cirrhotic patients. Methods. From January 1984 to December 2006, 310 alcoholic cirrhotic patients (242 men, 68 women; mean age 51.7 years) with AVH underwent 786 endoscopic variceal injection treatments (342 emergency, 444 elective) during 919 endoscopy sessions in the first 6 weeks after the first variceal bleed. Endoscopic control of initial bleeding, variceal rebleeding and survival at 6 weeks were recorded. Results. Endoscopic intervention controlled AVH in 304 of 310 patients (98.1%). Seventy-five patients (24.2%) rebled, 38 (12.3%) within 5 days and 37 (11.9%) within 6 weeks. No patient scored as Child-Pugh A died. Seventy-seven (24.8%) Child-Pugh B and C patients died, 29 (9.3%) within 5 days and 48 (15.4%) between 6 and 42 days. Mortality increased exponentially as the Child-Pugh score increased, reaching 80% when the score exceeded 13. Conclusion. Despite initial control of variceal haemorrhage, 1 in 4 patients (24.2%) rebled within 6 weeks. Survival at 6 weeks was 75.2% and was influenced by the severity of liver failure, with most deaths occurring in Child-Pugh grade C patients. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Surgery LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 SM - 2078-5151 T1 - Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy TI - Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy UR - http://hdl.handle.net/11427/22482 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/22482 | |
| dc.identifier.uri | http://sajs.redbricklibrary.com/index.php/sajs/article/view/1589 | |
| dc.identifier.vancouvercitation | Krige J, Kotze U, Shaw J, Bornman P. Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy. South African Journal of Surgery. 2009; http://hdl.handle.net/11427/22482. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher | Medpharm | |
| dc.publisher.department | Department of Surgery | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Journal of Surgery | |
| dc.source.uri | http://sajs.redbricklibrary.com/index.php/sajs/index | |
| dc.title | Early rebleeding and death at 6 weeks in alcoholic cirrhotic patients with acute variceal bleeding treated with emergency endoscopic injection sclerotherapy | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |