Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorKrein, Ze-even_ZA
dc.date.accessioned2014-08-13T14:26:43Z
dc.date.available2014-08-13T14:26:43Z
dc.date.issued2007en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 151-155).en_ZA
dc.description.abstractChloroquine (CQ) was previously identified as a potential anti-HIV agent and reported to inhibit the production of infectious viral particles at concentrations which are non toxic to human cultured cells. It is speculated that this activity is associated with the decreased production of the heavily glycosylated epitope 2G 12 which is found on the gp120 glycoprotein surface. The hypothesized mechanism involves CQ acting on a range of cellular targets. This work identifies CQ as a lead compound for the discovery of potentially inexpensive drugs and its ability to target cellular enzymes as opposed to viral enzymes may endow the compound with the capacity to oppose resistance. This previous work was the basis of this project and prompted a further investigation into whether the quinoline scaffold is the principal cause of CQ's activity and whether other rationally designed compounds which contain this scaffold would be able to maintain similar or even greater anti-HIV activity. In an attempt to achieve greater activity, the dual drug approach was utilized.en_ZA
dc.identifier.apacitationKrein, Z. (2007). <i>Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6320en_ZA
dc.identifier.chicagocitationKrein, Ze-ev. <i>"Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2007. http://hdl.handle.net/11427/6320en_ZA
dc.identifier.citationKrein, Z. 2007. Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Krein, Ze-ev AB - Chloroquine (CQ) was previously identified as a potential anti-HIV agent and reported to inhibit the production of infectious viral particles at concentrations which are non toxic to human cultured cells. It is speculated that this activity is associated with the decreased production of the heavily glycosylated epitope 2G 12 which is found on the gp120 glycoprotein surface. The hypothesized mechanism involves CQ acting on a range of cellular targets. This work identifies CQ as a lead compound for the discovery of potentially inexpensive drugs and its ability to target cellular enzymes as opposed to viral enzymes may endow the compound with the capacity to oppose resistance. This previous work was the basis of this project and prompted a further investigation into whether the quinoline scaffold is the principal cause of CQ's activity and whether other rationally designed compounds which contain this scaffold would be able to maintain similar or even greater anti-HIV activity. In an attempt to achieve greater activity, the dual drug approach was utilized. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria TI - Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria UR - http://hdl.handle.net/11427/6320 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6320
dc.identifier.vancouvercitationKrein Z. Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6320en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleUtilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malariaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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