The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study

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dc.contributor.authorDalvie, Mohameden_ZA
dc.contributor.authorMyers, Jonathanen_ZA
dc.date.accessioned2015-10-12T10:54:44Z
dc.date.available2015-10-12T10:54:44Z
dc.date.issued2006en_ZA
dc.description.abstractBACKGROUND:The utility of blood reproductive endocrine biomarkers for assessing or estimating semen quality was explored. METHODS: A cross-sectional study of 47 DDT exposed malaria vector control workers was performed. Tests included blood basal and post gonadotrophin releasing hormone (GnRH), lutenizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), estradiol (E2) and inhibin; a questionnaire (demographics and general medical history); a physical examination and semen analysis. Semen parameters were determined using either/or or both WHO or the strict Tygerberg criteria. Relationships between semen parameters and endocrine measures were adjusted for age, duration of abstinence before sampling, presence of physical abnormalities and fever in the last two months. All relationships between specific endocrine hormones were adjusted for age and basal SHBG. RESULTS: Multiple logistic regression showed a consistent positive relationship (prevalence odds ratio (POR) = 8.2, CI:1.4-49.2) between low basal inhibin (<100 pg/ml) and low semen count (< 40 million) and density (< 20 million/ml); consistent positive, but weaker relationships (1> POR < 2) between abnormally low semen count as well as density and baseline and post GnRH FSH; and positive relationships (POR = 37, CI:2-655) between the prevalence of high basal estradiol (> 50 pg/ml) and abnormal morphology (proportion < 5%) and low motility (proportion <50%). Most of the expected physiological relationships between specific endocrines were significant. CONCLUSION: The study has demonstrated that low basal inhibin, elevated basal FSH and high basal E2 can serve as markers of impaired semen quality.en_ZA
dc.identifier.apacitationDalvie, M., & Myers, J. (2006). The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. <i>Journal of Occupational Medicine and Toxicology</i>, http://hdl.handle.net/11427/14183en_ZA
dc.identifier.chicagocitationDalvie, Mohamed, and Jonathan Myers "The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study." <i>Journal of Occupational Medicine and Toxicology</i> (2006) http://hdl.handle.net/11427/14183en_ZA
dc.identifier.citationDalvie, M. A., & Myers, J. E. (2005). The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. J Occup Med Toxicol, 1(6).en_ZA
dc.identifier.ris TY - Journal Article AU - Dalvie, Mohamed AU - Myers, Jonathan AB - BACKGROUND:The utility of blood reproductive endocrine biomarkers for assessing or estimating semen quality was explored. METHODS: A cross-sectional study of 47 DDT exposed malaria vector control workers was performed. Tests included blood basal and post gonadotrophin releasing hormone (GnRH), lutenizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), estradiol (E2) and inhibin; a questionnaire (demographics and general medical history); a physical examination and semen analysis. Semen parameters were determined using either/or or both WHO or the strict Tygerberg criteria. Relationships between semen parameters and endocrine measures were adjusted for age, duration of abstinence before sampling, presence of physical abnormalities and fever in the last two months. All relationships between specific endocrine hormones were adjusted for age and basal SHBG. RESULTS: Multiple logistic regression showed a consistent positive relationship (prevalence odds ratio (POR) = 8.2, CI:1.4-49.2) between low basal inhibin (<100 pg/ml) and low semen count (< 40 million) and density (< 20 million/ml); consistent positive, but weaker relationships (1> POR < 2) between abnormally low semen count as well as density and baseline and post GnRH FSH; and positive relationships (POR = 37, CI:2-655) between the prevalence of high basal estradiol (> 50 pg/ml) and abnormal morphology (proportion < 5%) and low motility (proportion <50%). Most of the expected physiological relationships between specific endocrines were significant. CONCLUSION: The study has demonstrated that low basal inhibin, elevated basal FSH and high basal E2 can serve as markers of impaired semen quality. DA - 2006 DB - OpenUCT DO - 10.1186/1745-6673-1-21 DP - University of Cape Town J1 - Journal of Occupational Medicine and Toxicology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study TI - The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study UR - http://hdl.handle.net/11427/14183 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14183
dc.identifier.urihttp://dx.doi.org/10.1186/1745-6673-1-21
dc.identifier.vancouvercitationDalvie M, Myers J. The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. Journal of Occupational Medicine and Toxicology. 2006; http://hdl.handle.net/11427/14183.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentWomen's Health Research Uniten_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceJournal of Occupational Medicine and Toxicologyen_ZA
dc.source.urihttp://www.occup-med.comen_ZA
dc.subject.otherOccupational and Environmental Healthen_ZA
dc.titleThe relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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