Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study

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dc.contributor.authorNguimmo-Metsadjio, Aurelie
dc.contributor.authorAtogho-Tiedeu, Barbara
dc.contributor.authorNoubiap, Jean Jacques
dc.contributor.authorEvehe, Marie-Solange
dc.contributor.authorDjokam-Dadjeu, Rosine
dc.contributor.authorDonfack, Olivier Sontsa
dc.contributor.authorNanfa, Dieudonne
dc.contributor.authorMato, Edith Pascale M
dc.contributor.authorNgwa, Elvis Ndonwi
dc.contributor.authorGuewo-Fokeng, Magellan
dc.contributor.authorPokam-Fosso, Priscille
dc.contributor.authorMbacham, Wilfred F
dc.contributor.authorMbanya, Jean Claude
dc.contributor.authorSobngwi, Eugène
dc.date.accessioned2021-10-08T07:08:10Z
dc.date.available2021-10-08T07:08:10Z
dc.date.issued2017
dc.description.abstractOBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.
dc.identifier.apacitationNguimmo-Metsadjio, A., Atogho-Tiedeu, B., Noubiap, J. J., Evehe, M., Djokam-Dadjeu, R., Donfack, O. S., ... Sobngwi, E. (2017). Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. <i>Journal of Health, Population and Nutrition (JHPN)</i>, 36(1), 174 - 177. http://hdl.handle.net/11427/34516en_ZA
dc.identifier.chicagocitationNguimmo-Metsadjio, Aurelie, Barbara Atogho-Tiedeu, Jean Jacques Noubiap, Marie-Solange Evehe, Rosine Djokam-Dadjeu, Olivier Sontsa Donfack, Dieudonne Nanfa, et al "Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study." <i>Journal of Health, Population and Nutrition (JHPN)</i> 36, 1. (2017): 174 - 177. http://hdl.handle.net/11427/34516en_ZA
dc.identifier.citationNguimmo-Metsadjio, A., Atogho-Tiedeu, B., Noubiap, J.J., Evehe, M., Djokam-Dadjeu, R., Donfack, O.S., Nanfa, D. & Mato, E.P.M. et al. 2017. Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. <i>Journal of Health, Population and Nutrition (JHPN).</i> 36(1):174 - 177. http://hdl.handle.net/11427/34516en_ZA
dc.identifier.issn1606-0997
dc.identifier.issn2072-1315
dc.identifier.ris TY - Journal Article AU - Nguimmo-Metsadjio, Aurelie AU - Atogho-Tiedeu, Barbara AU - Noubiap, Jean Jacques AU - Evehe, Marie-Solange AU - Djokam-Dadjeu, Rosine AU - Donfack, Olivier Sontsa AU - Nanfa, Dieudonne AU - Mato, Edith Pascale M AU - Ngwa, Elvis Ndonwi AU - Guewo-Fokeng, Magellan AU - Pokam-Fosso, Priscille AU - Mbacham, Wilfred F AU - Mbanya, Jean Claude AU - Sobngwi, Eugène AB - OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Journal of Health, Population and Nutrition (JHPN) LK - https://open.uct.ac.za PY - 2017 SM - 1606-0997 SM - 2072-1315 T1 - Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study TI - Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study UR - http://hdl.handle.net/11427/34516 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34516
dc.identifier.vancouvercitationNguimmo-Metsadjio A, Atogho-Tiedeu B, Noubiap JJ, Evehe M, Djokam-Dadjeu R, Donfack OS, et al. Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. Journal of Health, Population and Nutrition (JHPN). 2017;36(1):174 - 177. http://hdl.handle.net/11427/34516.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceJournal of Health, Population and Nutrition (JHPN)
dc.source.journalissue1
dc.source.journalvolume36
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s41043-017-0087-z
dc.subject.otherCameroon
dc.subject.otherGenetic association
dc.subject.otherObesity
dc.subject.otherSub-Saharan Africa
dc.subject.otherTCF7L2
dc.subject.otherrs7903146 (C/T) polymorphism
dc.subject.otherAdult
dc.subject.otherAfrican Continental Ancestry Group
dc.subject.otherAlleles
dc.subject.otherCameroon
dc.subject.otherCase-Control Studies
dc.subject.otherFemale
dc.subject.otherGene Frequency
dc.subject.otherGenotype
dc.subject.otherHumans
dc.subject.otherLipids
dc.subject.otherMale
dc.subject.otherMiddle Aged
dc.subject.otherObesity
dc.subject.otherPilot Projects
dc.subject.otherPolymerase Chain Reaction
dc.subject.otherPolymorphism, Single Nucleotide
dc.titleErratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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