Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position

Simple item page
dc.contributor.authorHeffernan, S M
dc.contributor.authorStebbings, G K
dc.contributor.authorKilduff, L P
dc.contributor.authorErskine, R M
dc.contributor.authorDay, S H
dc.contributor.authorMorse, C. I
dc.contributor.authorMcPhee, J S
dc.contributor.authorCook, C J
dc.contributor.authorVance, B
dc.contributor.authorRibbans, W J
dc.contributor.authorRaleigh, S M
dc.contributor.authorRoberts, C
dc.contributor.authorBennett, M A
dc.contributor.authorWang, G
dc.contributor.authorCollins, M
dc.contributor.authorPitsiladis, Y P
dc.contributor.authorWilliams, A G
dc.date.accessioned2017-04-10T07:02:29Z
dc.date.available2017-04-10T07:02:29Z
dc.date.issued2017-01-19
dc.date.updated2017-01-19T19:03:13Z
dc.description.abstractBackground: FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes. Methods: In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the FTO rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; n = 120), we also assessed structural and functional skeletal muscle phenotypes using dual energy x-ray absorptiometry, ultrasound and isokinetic dynamometry. In a subgroup of rugby athletes (n = 77), we assessed muscle power during a countermovement jump. Results: In NT, TT genotype and T allele carriers had greater total body (4.8% and 4.1%) and total appendicular lean mass (LM; 3.0% and 2.1%) compared to AA genotype, with greater arm LM (0.8%) in T allele carriers and leg LM (2.1%) for TT, compared to AA genotype. Furthermore, the T allele was more common (94%) in selected elite rugby union athletes (back three and centre players) who are most reliant on LM rather than total body mass for success, compared to other rugby athletes (82%; P = 0.01, OR = 3.34) and controls (84%; P = 0.03, OR = 2.88). Accordingly, these athletes had greater peak power relative to body mass than other rugby athletes (14%; P = 2 x 10-6). Conclusion: Collectively, these results suggest that the T allele is associated with increased LM and elite athletic success. This has implications for athletic populations, as well as conditions characterised by low LM such as sarcopenia and cachexia.
dc.identifier.apacitationHeffernan, S. M., Stebbings, G. K., Kilduff, L. P., Erskine, R. M., Day, S. H., Morse, C. I., ... Williams, A. G. (2017). Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position. http://hdl.handle.net/11427/24165en_ZA
dc.identifier.chicagocitationHeffernan, S M, G K Stebbings, L P Kilduff, R M Erskine, S H Day, C. I Morse, J S McPhee, et al "Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position." (2017) http://hdl.handle.net/11427/24165en_ZA
dc.identifier.citationHeffernan, S. M., Stebbings, G. K., Kilduff, L. P., Erskine, R. M., Day, S. H., Morse, C. I., ... & Raleigh, S. M. (2017). Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position. BMC genetics, 18(1), 4.
dc.identifier.ris TY - Journal Article AU - Heffernan, S M AU - Stebbings, G K AU - Kilduff, L P AU - Erskine, R M AU - Day, S H AU - Morse, C. I AU - McPhee, J S AU - Cook, C J AU - Vance, B AU - Ribbans, W J AU - Raleigh, S M AU - Roberts, C AU - Bennett, M A AU - Wang, G AU - Collins, M AU - Pitsiladis, Y P AU - Williams, A G AB - Background: FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes. Methods: In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the FTO rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; n = 120), we also assessed structural and functional skeletal muscle phenotypes using dual energy x-ray absorptiometry, ultrasound and isokinetic dynamometry. In a subgroup of rugby athletes (n = 77), we assessed muscle power during a countermovement jump. Results: In NT, TT genotype and T allele carriers had greater total body (4.8% and 4.1%) and total appendicular lean mass (LM; 3.0% and 2.1%) compared to AA genotype, with greater arm LM (0.8%) in T allele carriers and leg LM (2.1%) for TT, compared to AA genotype. Furthermore, the T allele was more common (94%) in selected elite rugby union athletes (back three and centre players) who are most reliant on LM rather than total body mass for success, compared to other rugby athletes (82%; P = 0.01, OR = 3.34) and controls (84%; P = 0.03, OR = 2.88). Accordingly, these athletes had greater peak power relative to body mass than other rugby athletes (14%; P = 2 x 10-6). Conclusion: Collectively, these results suggest that the T allele is associated with increased LM and elite athletic success. This has implications for athletic populations, as well as conditions characterised by low LM such as sarcopenia and cachexia. DA - 2017-01-19 DB - OpenUCT DO - 10.1186/s12863-017-0470-1 DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position TI - Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position UR - http://hdl.handle.net/11427/24165 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12863-017-0470-1
dc.identifier.urihttp://hdl.handle.net/11427/24165
dc.identifier.vancouvercitationHeffernan SM, Stebbings GK, Kilduff LP, Erskine RM, Day SH, Morse C I, et al. Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position. 2017; http://hdl.handle.net/11427/24165.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s)
dc.subject.otherRugbyGene project
dc.subject.otherIRX3
dc.subject.otherLean mass
dc.titleFat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Heffernan_Article_2017.pdf
Size:
565.61 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles