An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing

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dc.contributor.advisorDavids, Lester Men_ZA
dc.contributor.authorChang, Ju-Weien_ZA
dc.date.accessioned2014-07-28T14:50:22Z
dc.date.available2014-07-28T14:50:22Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractOn healing, partial-thickness burn wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes. The lack of pigmentation in the healed wound is particularly prominent in dark-skinned individuals and could result in serious psychosocial consequences such as low self-esteem, stigmatisation and discrimination among sufferers. Methods aimed at investigating rapid and efficient repigmentation in wounded skin are therefore pertinent. The aims of this study were two-fold: i) To promote melanin synthesis in human skin cells using different ratios of human melanocytes (Mc) to keratinocytes (Kc) in an in vitro co-culture system, in order to ensure pigmentation of the skin and, ii) To understand cellular mechanisms that contribute basic scientific knowledge towards clinically improved wound healing.en_ZA
dc.identifier.apacitationChang, J. (2013). <i>An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/3067en_ZA
dc.identifier.chicagocitationChang, Ju-Wei. <i>"An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2013. http://hdl.handle.net/11427/3067en_ZA
dc.identifier.citationChang, J. 2013. An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Chang, Ju-Wei AB - On healing, partial-thickness burn wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes. The lack of pigmentation in the healed wound is particularly prominent in dark-skinned individuals and could result in serious psychosocial consequences such as low self-esteem, stigmatisation and discrimination among sufferers. Methods aimed at investigating rapid and efficient repigmentation in wounded skin are therefore pertinent. The aims of this study were two-fold: i) To promote melanin synthesis in human skin cells using different ratios of human melanocytes (Mc) to keratinocytes (Kc) in an in vitro co-culture system, in order to ensure pigmentation of the skin and, ii) To understand cellular mechanisms that contribute basic scientific knowledge towards clinically improved wound healing. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing TI - An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing UR - http://hdl.handle.net/11427/3067 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3067
dc.identifier.vancouvercitationChang J. An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3067en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleAn in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healingen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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