Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

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dc.contributor.authorChopera, Denis Ren_ZA
dc.contributor.authorWoodman, Zendaen_ZA
dc.contributor.authorMlisana, Kolekaen_ZA
dc.contributor.authorMlotshwa, Mandlaen_ZA
dc.contributor.authorMartin, Darren Pen_ZA
dc.contributor.authorSeoighe, Cathalen_ZA
dc.contributor.authorTreurnicht, Floretteen_ZA
dc.contributor.authorRosa, Debra Assis deen_ZA
dc.contributor.authorHide, Winstonen_ZA
dc.contributor.authorKarim, Salim Abdoolen_ZA
dc.date.accessioned2016-01-02T05:05:45Z
dc.date.available2016-01-02T05:05:45Z
dc.date.issued2008en_ZA
dc.description.abstractAuthor Summary Following infection with HIV, it is well established that a person's genetic makeup is a major determinant of how quickly they will progress to AIDS. Particularly important is the class I Human leukocyte antigen (HLA) gene that is responsible for alerting the immune system to HIV's presence. One of the reasons our immune systems are unable to beat HIV is that the virus can mutate to forms that our HLA genes no longer recognise. However, some people have versions of the HLA gene (for example HLA-B*57 and HLA-B*5801) that are known to force HIV to tolerate mutations that damage its ability to reproduce. Slower HIV reproduction is thought to be one reason that HLA-B*57 and HLA-B*5801 positive people progress to AIDS more slowly than most other HIV infected persons. We report here on a study of HLA-B*57 and HLA-B*5801 negative women in which better control of disease tended to be associated with their being infected with viruses carrying mutations that have been previously shown to reduce replication. These mutations characterise viruses found infecting HLA-B*57 and HLA-B*5801 positive people. This indicates for the first time that HLA-B*57 or HLA-B*5801 negative people that are infected by such reproductively compromised viruses may also experience better survival prospects.en_ZA
dc.identifier.apacitationChopera, D. R., Woodman, Z., Mlisana, K., Mlotshwa, M., Martin, D. P., Seoighe, C., ... Karim, S. A. (2008). Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage. <i>PLoS One</i>, http://hdl.handle.net/11427/16158en_ZA
dc.identifier.chicagocitationChopera, Denis R, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, and Salim Abdool Karim "Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/16158en_ZA
dc.identifier.citationChopera, D. R., Woodman, Z., Mlisana, K., Mlotshwa, M., Martin, D. P., Seoighe, C., ... & Gray, C. M. (2008). Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage. PLoS pathogens, 4(3), e1000033. doi:10.1371/journal.ppat.1000033en_ZA
dc.identifier.ris TY - Journal Article AU - Chopera, Denis R AU - Woodman, Zenda AU - Mlisana, Koleka AU - Mlotshwa, Mandla AU - Martin, Darren P AU - Seoighe, Cathal AU - Treurnicht, Florette AU - Rosa, Debra Assis de AU - Hide, Winston AU - Karim, Salim Abdool AB - Author Summary Following infection with HIV, it is well established that a person's genetic makeup is a major determinant of how quickly they will progress to AIDS. Particularly important is the class I Human leukocyte antigen (HLA) gene that is responsible for alerting the immune system to HIV's presence. One of the reasons our immune systems are unable to beat HIV is that the virus can mutate to forms that our HLA genes no longer recognise. However, some people have versions of the HLA gene (for example HLA-B*57 and HLA-B*5801) that are known to force HIV to tolerate mutations that damage its ability to reproduce. Slower HIV reproduction is thought to be one reason that HLA-B*57 and HLA-B*5801 positive people progress to AIDS more slowly than most other HIV infected persons. We report here on a study of HLA-B*57 and HLA-B*5801 negative women in which better control of disease tended to be associated with their being infected with viruses carrying mutations that have been previously shown to reduce replication. These mutations characterise viruses found infecting HLA-B*57 and HLA-B*5801 positive people. This indicates for the first time that HLA-B*57 or HLA-B*5801 negative people that are infected by such reproductively compromised viruses may also experience better survival prospects. DA - 2008 DB - OpenUCT DO - 10.1371/journal.ppat.1000033 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage TI - Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage UR - http://hdl.handle.net/11427/16158 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16158
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1000033
dc.identifier.vancouvercitationChopera DR, Woodman Z, Mlisana K, Mlotshwa M, Martin DP, Seoighe C, et al. Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage. PLoS One. 2008; http://hdl.handle.net/11427/16158.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2008 Chopera et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherMicrobial mutationen_ZA
dc.subject.otherViral loaden_ZA
dc.subject.otherMutation detectionen_ZA
dc.subject.otherMutationen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherViral replicationen_ZA
dc.subject.otherEnzyme-linked immunoassaysen_ZA
dc.titleTransmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantageen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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