Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization
| dc.contributor.author | Mazidi, Mohsen | |
| dc.contributor.author | Kengne, Andre P. | |
| dc.contributor.author | Siervo, Mario | |
| dc.contributor.author | Kirwan, Richard | |
| dc.date.accessioned | 2022-04-13T09:44:10Z | |
| dc.date.available | 2022-04-13T09:44:10Z | |
| dc.date.issued | 2022-03-15 | |
| dc.date.updated | 2022-03-24T14:47:23Z | |
| dc.description.abstract | Polyunsaturated fatty acid (PUFA) intake is generally associated with better renal function, while the association of monounsaturated fatty acids (MUFAs) remains unconfirmed. Mendelian randomization (MR) analysis was used to obtain unconfounded estimates of the causal association of dietary intake and genetically determined serum PUFA and MUFA levels with measures of renal function. Data from participants of the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2010 were used. Data from the largest genome-wide association studies (GWAS) on MUFAs, PUFAs, eGFR, and chronic kidney disease (CKD) were analysed for the entire sample. A total of 16,025 participants were included. eGFR improved across increasing quartiles of total PUFA intake from 86.3 ± 0.5 (Q1) to 96.2 ± 0.5 mL/min/1.73 m² (Q4), (<i>p</i> < 0.001). Conversely, there was no association between MUFA intake and measures of renal function (all <i>p</i> > 0.21). In multivariable models, the top quartile of PUFA intake had a 21% lower risk for CKD, but there was no significant association between CKD risk and MUFA intake. Genetically determined serum MUFA (heptadecenoate (17:1), myristoleic acid (14:1), and palmitoleic acid (16:1)) and PUFA (α-linolenic acid and eicosapentaenoic acid) concentrations had no significant association with eGFR and CKD risk. Additionally, no association was found in the analyses stratified by diabetes status. Higher dietary PUFA intake is associated with lower risk of CKD, while there was no association with serum levels of MUFAs or PUFAs. Additional studies including clinical trials are warranted. | |
| dc.identifier | doi: 10.3390/nu14061231 | |
| dc.identifier.apacitation | Mazidi, M., Kengne, Andre P., Siervo, M., & Kirwan, R. (2022). Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization. <i>Nutrients</i>, 14(6), http://hdl.handle.net/11427/36369 | en_ZA |
| dc.identifier.chicagocitation | Mazidi, Mohsen, Andre P. Kengne, Mario Siervo, and Richard Kirwan "Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization." <i>Nutrients</i> 14, 6. (2022) http://hdl.handle.net/11427/36369 | en_ZA |
| dc.identifier.citation | Nutrients 14 (6): 1231 (2022) | |
| dc.identifier.ris | TY - Journal Article AU - Mazidi, Mohsen AU - Kengne, Andre P. AU - Siervo, Mario AU - Kirwan, Richard AB - Polyunsaturated fatty acid (PUFA) intake is generally associated with better renal function, while the association of monounsaturated fatty acids (MUFAs) remains unconfirmed. Mendelian randomization (MR) analysis was used to obtain unconfounded estimates of the causal association of dietary intake and genetically determined serum PUFA and MUFA levels with measures of renal function. Data from participants of the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2010 were used. Data from the largest genome-wide association studies (GWAS) on MUFAs, PUFAs, eGFR, and chronic kidney disease (CKD) were analysed for the entire sample. A total of 16,025 participants were included. eGFR improved across increasing quartiles of total PUFA intake from 86.3 ± 0.5 (Q1) to 96.2 ± 0.5 mL/min/1.73 m² (Q4), (<i>p</i> < 0.001). Conversely, there was no association between MUFA intake and measures of renal function (all <i>p</i> > 0.21). In multivariable models, the top quartile of PUFA intake had a 21% lower risk for CKD, but there was no significant association between CKD risk and MUFA intake. Genetically determined serum MUFA (heptadecenoate (17:1), myristoleic acid (14:1), and palmitoleic acid (16:1)) and PUFA (α-linolenic acid and eicosapentaenoic acid) concentrations had no significant association with eGFR and CKD risk. Additionally, no association was found in the analyses stratified by diabetes status. Higher dietary PUFA intake is associated with lower risk of CKD, while there was no association with serum levels of MUFAs or PUFAs. Additional studies including clinical trials are warranted. DA - 2022-03-15 DB - OpenUCT DP - University of Cape Town IS - 6 J1 - Nutrients KW - mendelian randomization KW - serum fatty acids KW - monounsaturated fatty acids LK - https://open.uct.ac.za PY - 2022 T1 - Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization TI - Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization UR - http://hdl.handle.net/11427/36369 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/36369 | |
| dc.identifier.uri | https://doi.org/10.3390/nu14061231 | |
| dc.identifier.vancouvercitation | Mazidi M, Kengne Andre P, Siervo M, Kirwan R. Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization. Nutrients. 2022;14(6) http://hdl.handle.net/11427/36369. | en_ZA |
| dc.publisher | Multidisciplinary Digital Publishing Institute | |
| dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.source | Nutrients | |
| dc.source | https://www.mdpi.com/journal/nutrients | |
| dc.source.journalissue | 6 | |
| dc.source.journalvolume | 14 | |
| dc.subject | mendelian randomization | |
| dc.subject | serum fatty acids | |
| dc.subject | monounsaturated fatty acids | |
| dc.subject | chronic kidney disease | |
| dc.subject | polyunsaturated fatty acids | |
| dc.subject | renal function | |
| dc.title | Association of Dietary Intakes and Genetically Determined Serum Concentrations of Mono and Poly Unsaturated Fatty Acids on Chronic Kidney Disease: Insights from Dietary Analysis and Mendelian Randomization | |
| dc.type | Journal Article |