Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype

Simple item page
dc.contributor.advisorEgan, Timothy Jen_ZA
dc.contributor.advisorHunter, Rogeren_ZA
dc.contributor.authorMvumvu, Nomakhwezien_ZA
dc.date.accessioned2015-12-09T14:47:09Z
dc.date.available2015-12-09T14:47:09Z
dc.date.issued2015en_ZA
dc.description.abstractThe blood stage of the malarial parasite life-cycle is a vital stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification pathway) that gives rise to the unique, microcrystalline ferriprotoporphryin IX [Fe(III)PPIX] dimer called haemozoin as an end-product, also arises as a result of the degradation. This haem detoxification pathway is a principal target for some of these antimalarials, especially those that contain the quinoline scaffold (e.g chloroquine), and has yielded outstanding results for the antimalarial drug discovery and development world. Even so, the spread of parasite resistance among these drugs has rendered most ineffective, resulting in a need for new scaffolds to target the pathway. However, the mode of action of chloroquine on haem may still be used as a model for identification of hits from these new scaffolds.en_ZA
dc.identifier.apacitationMvumvu, N. (2015). <i>Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/15743en_ZA
dc.identifier.chicagocitationMvumvu, Nomakhwezi. <i>"Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2015. http://hdl.handle.net/11427/15743en_ZA
dc.identifier.citationMvumvu, N. 2015. Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mvumvu, Nomakhwezi AB - The blood stage of the malarial parasite life-cycle is a vital stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification pathway) that gives rise to the unique, microcrystalline ferriprotoporphryin IX [Fe(III)PPIX] dimer called haemozoin as an end-product, also arises as a result of the degradation. This haem detoxification pathway is a principal target for some of these antimalarials, especially those that contain the quinoline scaffold (e.g chloroquine), and has yielded outstanding results for the antimalarial drug discovery and development world. Even so, the spread of parasite resistance among these drugs has rendered most ineffective, resulting in a need for new scaffolds to target the pathway. However, the mode of action of chloroquine on haem may still be used as a model for identification of hits from these new scaffolds. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype TI - Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype UR - http://hdl.handle.net/11427/15743 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15743
dc.identifier.vancouvercitationMvumvu N. Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/15743en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleSynthesis of 1,4 Dihydropyridines as potential antimalarial chemotypeen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2015_mvumvu_nomakhwezi.pdf
Size:
3.39 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters