Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort

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dc.contributor.authorLandais, Eliseen_ZA
dc.contributor.authorHuang, Xiayuen_ZA
dc.contributor.authorHavenar-Daughton, Colinen_ZA
dc.contributor.authorMurrell, Benen_ZA
dc.contributor.authorPrice, Matt Aen_ZA
dc.contributor.authorWickramasinghe, Lalindaen_ZA
dc.contributor.authorRamos, Alejandraen_ZA
dc.contributor.authorBian, Charoan Ben_ZA
dc.contributor.authorSimek, Melissaen_ZA
dc.contributor.authorAllen, Susanen_ZA
dc.contributor.authorKarita, Etienneen_ZA
dc.contributor.authorKilembe, Williamen_ZA
dc.contributor.authorLakhi, Shabiren_ZA
dc.contributor.authorInambao, Mubianaen_ZA
dc.contributor.authorKamali, Anatolien_ZA
dc.contributor.authorSanders, Eduard Jen_ZA
dc.contributor.authorAnzala, Omuen_ZA
dc.contributor.authorEdward, Vinodhen_ZA
dc.contributor.authorBekker, Linda-Gailen_ZA
dc.contributor.authorTang, Jianmingen_ZA
dc.contributor.authorGilmour, Jillen_ZA
dc.contributor.authorKosakovsky-Pond, Sergei Len_ZA
dc.contributor.authorPhung, Phamen_ZA
dc.contributor.authorWrin, Terrien_ZA
dc.contributor.authorCrotty, Shaneen_ZA
dc.contributor.authorGodzik, Adamen_ZA
dc.contributor.authorPoignard, Pascalen_ZA
dc.date.accessioned2016-02-10T14:45:27Z
dc.date.available2016-02-10T14:45:27Z
dc.date.issued2016en_ZA
dc.description.abstractAuthor Summary Understanding how HIV-1-broadly neutralizing antibodies (bnAbs) develop during natural infection is essential to the design of an efficient HIV vaccine. We studied kinetics and correlates of neutralization breadth in a large sub-Saharan African longitudinal cohort of 439 participants with primary HIV-1 infection. Broadly nAb responses developed in 15% of individuals, on average three years after infection. Broad neutralization was associated with high viral load, low CD4+ T cell counts, virus subtype C infection and HLA*A3(-) genotype. A correlation with high overall plasma IgG levels and anti-Env binding titers was also found. Specificity mapping of the bnAb responses showed that glycan-dependent epitopes, in particular the N332 region, were most commonly targeted, in contrast to other bnAb epitopes, suggesting that the HIV Env N332-glycan epitope region may be a favorable target for vaccine design.en_ZA
dc.identifier.apacitationLandais, E., Huang, X., Havenar-Daughton, C., Murrell, B., Price, M. A., Wickramasinghe, L., ... Poignard, P. (2016). Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. <i>PLoS One</i>, http://hdl.handle.net/11427/16943en_ZA
dc.identifier.chicagocitationLandais, Elise, Xiayu Huang, Colin Havenar-Daughton, Ben Murrell, Matt A Price, Lalinda Wickramasinghe, Alejandra Ramos, et al "Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/16943en_ZA
dc.identifier.citationLandais, E., Huang, X., Havenar-Daughton, C., Murrell, B., Price, M. A., Wickramasinghe, L., ... & Karita, E. (2016). Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. PLoS pathogens, 12(1), e1005369. doi:10.1371/journal.ppat.1005369en_ZA
dc.identifier.ris TY - Journal Article AU - Landais, Elise AU - Huang, Xiayu AU - Havenar-Daughton, Colin AU - Murrell, Ben AU - Price, Matt A AU - Wickramasinghe, Lalinda AU - Ramos, Alejandra AU - Bian, Charoan B AU - Simek, Melissa AU - Allen, Susan AU - Karita, Etienne AU - Kilembe, William AU - Lakhi, Shabir AU - Inambao, Mubiana AU - Kamali, Anatoli AU - Sanders, Eduard J AU - Anzala, Omu AU - Edward, Vinodh AU - Bekker, Linda-Gail AU - Tang, Jianming AU - Gilmour, Jill AU - Kosakovsky-Pond, Sergei L AU - Phung, Pham AU - Wrin, Terri AU - Crotty, Shane AU - Godzik, Adam AU - Poignard, Pascal AB - Author Summary Understanding how HIV-1-broadly neutralizing antibodies (bnAbs) develop during natural infection is essential to the design of an efficient HIV vaccine. We studied kinetics and correlates of neutralization breadth in a large sub-Saharan African longitudinal cohort of 439 participants with primary HIV-1 infection. Broadly nAb responses developed in 15% of individuals, on average three years after infection. Broad neutralization was associated with high viral load, low CD4+ T cell counts, virus subtype C infection and HLA*A3(-) genotype. A correlation with high overall plasma IgG levels and anti-Env binding titers was also found. Specificity mapping of the bnAb responses showed that glycan-dependent epitopes, in particular the N332 region, were most commonly targeted, in contrast to other bnAb epitopes, suggesting that the HIV Env N332-glycan epitope region may be a favorable target for vaccine design. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005369 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort TI - Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort UR - http://hdl.handle.net/11427/16943 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1005369en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16943
dc.identifier.vancouvercitationLandais E, Huang X, Havenar-Daughton C, Murrell B, Price MA, Wickramasinghe L, et al. Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. PLoS One. 2016; http://hdl.handle.net/11427/16943.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Landais et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherViral loaden_ZA
dc.subject.otherAntibody responseen_ZA
dc.subject.otherAntibodiesen_ZA
dc.subject.otherHIV-2en_ZA
dc.subject.otherAdsorptionen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherT helper cellsen_ZA
dc.titleBroadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohorten_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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