The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas

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dc.contributor.authorLondon, Leslieen_ZA
dc.contributor.authorCoggon, Daviden_ZA
dc.contributor.authorMoretto, Angeloen_ZA
dc.contributor.authorWesterholm, Peteren_ZA
dc.contributor.authorWilks, Martinen_ZA
dc.contributor.authorColosio, Claudioen_ZA
dc.date.accessioned2015-11-11T12:03:50Z
dc.date.available2015-11-11T12:03:50Z
dc.date.issued2010en_ZA
dc.description.abstractThe controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a) a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b) an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c) application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter.en_ZA
dc.identifier.apacitationLondon, L., Coggon, D., Moretto, A., Westerholm, P., Wilks, M., & Colosio, C. (2010). The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas. <i>Environmental Health</i>, http://hdl.handle.net/11427/14907en_ZA
dc.identifier.chicagocitationLondon, Leslie, David Coggon, Angelo Moretto, Peter Westerholm, Martin Wilks, and Claudio Colosio "The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas." <i>Environmental Health</i> (2010) http://hdl.handle.net/11427/14907en_ZA
dc.identifier.citationLondon, L., Coggon, D., Moretto, A., Westerholm, P., Wilks, M. F., & Colosio, C. (2010). The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas. Environmental health, 9(1), 50-66.en_ZA
dc.identifier.ris TY - Journal Article AU - London, Leslie AU - Coggon, David AU - Moretto, Angelo AU - Westerholm, Peter AU - Wilks, Martin AU - Colosio, Claudio AB - The controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a) a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b) an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c) application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter. DA - 2010 DB - OpenUCT DO - 10.1186/1476-069X-9-50 DP - University of Cape Town J1 - Environmental Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas TI - The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas UR - http://hdl.handle.net/11427/14907 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14907
dc.identifier.urihttp://dx.doi.org/10.1186/1476-069X-9-50
dc.identifier.vancouvercitationLondon L, Coggon D, Moretto A, Westerholm P, Wilks M, Colosio C. The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas. Environmental Health. 2010; http://hdl.handle.net/11427/14907.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentOccupational and Environmental Health RUen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2010 London et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceEnvironmental Healthen_ZA
dc.source.urihttp://www.ehjournal.net/en_ZA
dc.subject.otherBiomedical Researchen_ZA
dc.subject.otherEnvironmental Exposureen_ZA
dc.subject.otherEthics, Researchen_ZA
dc.subject.otherPesticidesen_ZA
dc.titleThe ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmasen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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